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UBA6

GENERAL INFORMATION

Gene name

 UBA6

Gene description

 Ubiquitin-like modifier activating enzyme 6

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in spermatozoa.

DATA RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA037001
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 UBA6 (HGNC Symbol)

Synonyms

 FLJ10808, UBE1L2

Description

 Ubiquitin-like modifier activating enzyme 6 (HGNC Symbol)

Entrez gene summary

 Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al., 2007 [PubMed 17597759]).[supplied by OMIM, Mar 2008]

Chromosome

 4

Cytoband

 q13.2

Chromosome location (bp)

 67612652 - 67701179

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000033178 (version 83.38)

Entrez gene

 55236

UniProt

 A0AVT1 (UniProt - Evidence at protein level)

neXtProt

 NX_A0AVT1

Antibodypedia

 UBA6 antibodies

PROTEIN BROWSER
UBA6-001
UBA6-002
UBA6-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UBA6-001
ENSP00000313454
ENST00000322244
A0AVT1 [Direct mapping]
Ubiquitin-like modifier-activating enzyme 6
A0A024RDB0 [Target identity:100%; Query identity:100%]
Ubiquitin-activating enzyme E1-like 2, isoform CRA_a
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Enzymes
   ENZYME proteins
   Ligase
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004839 [ubiquitin activating enzyme activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007612 [learning]
GO:0007626 [locomotory behavior]
GO:0008641 [small protein activating enzyme activity]
GO:0016567 [protein ubiquitination]
GO:0019780 [FAT10 activating enzyme activity]
GO:0021764 [amygdala development]
GO:0021766 [hippocampus development]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0060996 [dendritic spine development]
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 1052 aa
118 kDa 		No 0
UBA6-002
ENSP00000399234
ENST00000420827
A0AVT1 [Direct mapping]
Ubiquitin-like modifier-activating enzyme 6
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004839 [ubiquitin activating enzyme activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008641 [small protein activating enzyme activity]
GO:0016567 [protein ubiquitination]
GO:0019780 [FAT10 activating enzyme activity]
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 389 aa
43.2 kDa 		No 0
UBA6-005
ENSP00000421984
ENST00000505673
H0Y8S8 [Direct mapping]
Ubiquitin-like modifier-activating enzyme 6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006464 [cellular protein modification process]
GO:0008641 [small protein activating enzyme activity]
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 271 aa
30.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.