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ATP6V0A1

CANCER ATLAS

Gene description

 ATPase, H+ transporting, lysosomal V0 subunit a1

Protein class

 Predicted intracellular proteins, Predicted membrane proteins, Transporters

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA022144

GENE INFORMATION

Gene name

 ATP6V0A1 (HGNC Symbol)

Synonyms

 a1, ATP6N1, ATP6N1A, Stv1, Vph1, VPP1

Description

 ATPase, H+ transporting, lysosomal V0 subunit a1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c"", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.2

Chromosome location (bp)

 42458844 - 42522611

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000033627 (version 83.38)

Entrez gene

 535

UniProt

 Q93050 (UniProt - Evidence at protein level)

neXtProt

 NX_Q93050

Antibodypedia

 ATP6V0A1 antibodies

PROTEIN BROWSER
«
ATP6V0A1-001
ATP6V0A1-003
ATP6V0A1-004
ATP6V0A1-005
ATP6V0A1-006
ATP6V0A1-012
ATP6V0A1-013
ATP6V0A1-014
ATP6V0A1-017
ATP6V0A1-022
ATP6V0A1-025
ATP6V0A1-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP6V0A1-001
ENSP00000377415
ENST00000393829
Q93050 [Direct mapping]
V-type proton ATPase 116 kDa subunit a isoform 1
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000220 [vacuolar proton-transporting V-type ATPase, V0 domain]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006879 [cellular iron ion homeostasis]
GO:0007035 [vacuolar acidification]
GO:0008286 [insulin receptor signaling pathway]
GO:0010008 [endosome membrane]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016021 [integral component of membrane]
GO:0016471 [vacuolar proton-transporting V-type ATPase complex]
GO:0030670 [phagocytic vesicle membrane]
GO:0033179 [proton-transporting V-type ATPase, V0 domain]
GO:0033572 [transferrin transport]
GO:0034220 [ion transmembrane transport]
GO:0042470 [melanosome]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0051117 [ATPase binding]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly]
GO:0090382 [phagosome maturation]
Show all
 831 aa
95.8 kDa 		No 7
ATP6V0A1-003
ENSP00000443991
ENST00000537728
B7Z641 [Direct mapping]
V-type proton ATPase subunit a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000220 [vacuolar proton-transporting V-type ATPase, V0 domain]
GO:0007035 [vacuolar acidification]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016021 [integral component of membrane]
GO:0016471 [vacuolar proton-transporting V-type ATPase complex]
GO:0033179 [proton-transporting V-type ATPase, V0 domain]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly]
Show all
 788 aa
90.5 kDa 		No 7
ATP6V0A1-004
ENSP00000264649
ENST00000264649
Q93050 [Direct mapping]
V-type proton ATPase 116 kDa subunit a isoform 1
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000220 [vacuolar proton-transporting V-type ATPase, V0 domain]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006879 [cellular iron ion homeostasis]
GO:0007035 [vacuolar acidification]
GO:0008286 [insulin receptor signaling pathway]
GO:0010008 [endosome membrane]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016021 [integral component of membrane]
GO:0016471 [vacuolar proton-transporting V-type ATPase complex]
GO:0030670 [phagocytic vesicle membrane]
GO:0033179 [proton-transporting V-type ATPase, V0 domain]
GO:0033572 [transferrin transport]
GO:0034220 [ion transmembrane transport]
GO:0042470 [melanosome]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0051117 [ATPase binding]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly]
GO:0090382 [phagosome maturation]
GO:1901998 [toxin transport]
Show all
 838 aa
96.6 kDa 		No 7
ATP6V0A1-005
ENSP00000466878
ENST00000585525
B7Z2A9 [Direct mapping]
V-type proton ATPase subunit a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000220 [vacuolar proton-transporting V-type ATPase, V0 domain]
GO:0007035 [vacuolar acidification]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016021 [integral component of membrane]
GO:0016471 [vacuolar proton-transporting V-type ATPase complex]
GO:0033179 [proton-transporting V-type ATPase, V0 domain]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly]
Show all
 794 aa
91.2 kDa 		No 7
ATP6V0A1-006
ENSP00000342951
ENST00000343619
Q93050 [Direct mapping]
V-type proton ATPase 116 kDa subunit a isoform 1
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000220 [vacuolar proton-transporting V-type ATPase, V0 domain]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006879 [cellular iron ion homeostasis]
GO:0007035 [vacuolar acidification]
GO:0008286 [insulin receptor signaling pathway]
GO:0010008 [endosome membrane]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016021 [integral component of membrane]
GO:0016471 [vacuolar proton-transporting V-type ATPase complex]
GO:0030670 [phagocytic vesicle membrane]
GO:0033179 [proton-transporting V-type ATPase, V0 domain]
GO:0033572 [transferrin transport]
GO:0034220 [ion transmembrane transport]
GO:0042470 [melanosome]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0051117 [ATPase binding]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly]
GO:0090382 [phagosome maturation]
Show all
 837 aa
96.4 kDa 		No 7
ATP6V0A1-012
ENSP00000466328
ENST00000587824
K7EM24 [Direct mapping]
V-type proton ATPase subunit a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0007035 [vacuolar acidification]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016471 [vacuolar proton-transporting V-type ATPase complex]
GO:0033179 [proton-transporting V-type ATPase, V0 domain]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly]
Show all
 130 aa
15.4 kDa 		No 0
ATP6V0A1-013
ENSP00000466290
ENST00000589213
K7ELZ6 [Direct mapping]
V-type proton ATPase subunit a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007035 [vacuolar acidification]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016471 [vacuolar proton-transporting V-type ATPase complex]
GO:0033179 [proton-transporting V-type ATPase, V0 domain]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly]
Show all
 93 aa
10.9 kDa 		No 0
ATP6V0A1-014
ENSP00000467373
ENST00000589727
K7EPG4 [Direct mapping]
V-type proton ATPase subunit a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007035 [vacuolar acidification]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016471 [vacuolar proton-transporting V-type ATPase complex]
GO:0033179 [proton-transporting V-type ATPase, V0 domain]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly]
Show all
 198 aa
23 kDa 		No 0
ATP6V0A1-017
ENSP00000466767
ENST00000592324
K7EN36 [Direct mapping]
V-type proton ATPase subunit a
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007035 [vacuolar acidification]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016471 [vacuolar proton-transporting V-type ATPase complex]
GO:0033179 [proton-transporting V-type ATPase, V0 domain]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly]
Show all
 195 aa
22.5 kDa 		No 0
ATP6V0A1-022
ENSP00000466852
ENST00000588138
K7ENA1 [Direct mapping]
V-type proton ATPase subunit a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007035 [vacuolar acidification]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016021 [integral component of membrane]
GO:0016471 [vacuolar proton-transporting V-type ATPase complex]
GO:0033179 [proton-transporting V-type ATPase, V0 domain]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly]
Show all
 191 aa
21.2 kDa 		No 2
ATP6V0A1-025
ENSP00000468177
ENST00000586201
K7ERA6 [Direct mapping]
V-type proton ATPase subunit a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007035 [vacuolar acidification]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016021 [integral component of membrane]
GO:0016471 [vacuolar proton-transporting V-type ATPase complex]
GO:0033179 [proton-transporting V-type ATPase, V0 domain]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly]
Show all
 188 aa
20.8 kDa 		No 1
ATP6V0A1-201
ENSP00000446377
ENST00000544137
F5H1T6 [Direct mapping]
V-type proton ATPase subunit a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007035 [vacuolar acidification]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016021 [integral component of membrane]
GO:0016471 [vacuolar proton-transporting V-type ATPase complex]
GO:0033179 [proton-transporting V-type ATPase, V0 domain]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly]
Show all
 483 aa
55.2 kDa 		No 7

Contact

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.