Fields »
ABOUT
HELP
BLOG
PIAS1

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 PIAS1

Gene description

 Protein inhibitor of activated STAT, 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the microtubules.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Microtubules (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA005743
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the microtubules.

Main location

 Microtubules (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA005743 A-431 Microtubules
HPA005743 U-2 OS Microtubules
HPA005743 U-251 MG Microtubules

GENE INFORMATION

Gene name

 PIAS1 (HGNC Symbol)

Synonyms

 DDXBP1, GBP, GU/RH-II, ZMIZ3

Description

 Protein inhibitor of activated STAT, 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q23

Chromosome location (bp)

 68054179 - 68198603

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000033800 (version 83.38)

Entrez gene

 8554

UniProt

 O75925 (UniProt - Evidence at protein level)

neXtProt

 NX_O75925

Antibodypedia

 PIAS1 antibodies

PROTEIN BROWSER
PIAS1-001
PIAS1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PIAS1-001
ENSP00000249636
ENST00000249636
O75925 [Direct mapping]
E3 SUMO-protein ligase PIAS1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007259 [JAK-STAT cascade]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0016605 [PML body]
GO:0016607 [nuclear speck]
GO:0016874 [ligase activity]
GO:0016925 [protein sumoylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030521 [androgen receptor signaling pathway]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0033235 [positive regulation of protein sumoylation]
GO:0042127 [regulation of cell proliferation]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045444 [fat cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050681 [androgen receptor binding]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0061665 [SUMO ligase activity]
Show all
 651 aa
71.8 kDa 		No 0
PIAS1-002
ENSP00000438574
ENST00000545237
O75925 [Direct mapping]
E3 SUMO-protein ligase PIAS1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007259 [JAK-STAT cascade]
GO:0008270 [zinc ion binding]
GO:0016605 [PML body]
GO:0016607 [nuclear speck]
GO:0016874 [ligase activity]
GO:0016925 [protein sumoylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030521 [androgen receptor signaling pathway]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0033235 [positive regulation of protein sumoylation]
GO:0042127 [regulation of cell proliferation]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050681 [androgen receptor binding]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0061665 [SUMO ligase activity]
Show all
 653 aa
72.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.