Cell atlas - APBA2 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	APBA2
Gene description	Amyloid beta (A4) precursor protein-binding, family A, member 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane, the Golgi apparatus & vesicles. In addition localized to the nucleoplasm.
RNA cell category	Cell line enhanced (SH-SY5Y, U-937)
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (approved), Vesicles (approved), Plasma membrane (approved)
Additional location	In addition localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA039400
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SH-SY5Y, U-937) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane, the Golgi apparatus & vesicles. In addition localized to the nucleoplasm.

Main location

Golgi apparatus (approved), Vesicles (approved), Plasma membrane (approved)

Additional location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA039400	HEK 293	Nucleoplasm
HPA039400	HEK 293	Golgi apparatus
HPA039400	PC-3	Nucleoplasm
		Vesicles
		Plasma membrane
HPA039400	U-2 OS	Golgi apparatus
HPA039400	U-2 OS	Plasma membrane

GENE INFORMATION
Gene name	APBA2 (HGNC Symbol)
Synonyms	D15S1518E, HsT16821, LIN-10, MGC:14091, MINT2, X11L
Description	Amyloid beta (A4) precursor protein-binding, family A, member 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q13.1
Chromosome location (bp)	28884483 - 29118315
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000034053 (version 83.38)
Entrez gene	321
UniProt	Q99767 (UniProt - Evidence at protein level)
neXtProt	NX_Q99767
Antibodypedia	APBA2 antibodies

PROTEIN BROWSER

APBA2-001	APBA2-002	APBA2-004	APBA2-007	APBA2-008	APBA2-009	APBA2-010	APBA2-011	APBA2-201	APBA2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APBA2-001 ENSP00000453293 ENST00000558402	Q99767 [Direct mapping] Amyloid beta A4 precursor protein-binding family A member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0001701 [in utero embryonic development] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007268 [synaptic transmission] GO:0007399 [nervous system development] GO:0007626 [locomotory behavior] GO:0008021 [synaptic vesicle] GO:0010468 [regulation of gene expression] GO:0015031 [protein transport] GO:0035264 [multicellular organism growth] Show all	749 aa 82.5 kDa	No	0
APBA2-002 ENSP00000452722 ENST00000558330	Q99767 [Direct mapping] Amyloid beta A4 precursor protein-binding family A member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007399 [nervous system development] GO:0008021 [synaptic vesicle] GO:0015031 [protein transport] Show all	737 aa 81.1 kDa	No	0
APBA2-004 ENSP00000453144 ENST00000561069	Q99767 [Direct mapping] Amyloid beta A4 precursor protein-binding family A member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007399 [nervous system development] GO:0008021 [synaptic vesicle] GO:0015031 [protein transport] Show all	749 aa 82.5 kDa	No	0
APBA2-007 ENSP00000452699 ENST00000559709		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		4 aa 0.5 kDa	No	0
APBA2-008 ENSP00000454001 ENST00000558804	H0YNG7 [Direct mapping] Amyloid beta A4 precursor protein-binding family A member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0007268 [synaptic transmission] GO:0008021 [synaptic vesicle] Show all	70 aa 7.7 kDa	No	0
APBA2-009 ENSP00000453034 ENST00000560283	H0YL28 [Direct mapping] Amyloid beta A4 precursor protein-binding family A member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0007268 [synaptic transmission] GO:0008021 [synaptic vesicle] Show all	112 aa 12.6 kDa	No	0
APBA2-010 ENSP00000453981 ENST00000558206	H0YNE8 [Direct mapping] Amyloid beta A4 precursor protein-binding family A member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		27 aa 3 kDa	No	0
APBA2-011 ENSP00000453715 ENST00000558358	H0YMS0 [Direct mapping] Amyloid beta A4 precursor protein-binding family A member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0007268 [synaptic transmission] GO:0008021 [synaptic vesicle] Show all	264 aa 29.2 kDa	No	0
APBA2-201 ENSP00000409312 ENST00000411764	Q99767 [Direct mapping] Amyloid beta A4 precursor protein-binding family A member 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007399 [nervous system development] GO:0008021 [synaptic vesicle] GO:0015031 [protein transport] Show all	737 aa 81.1 kDa	No	0
APBA2-202 ENSP00000454171 ENST00000558259	Q99767 [Direct mapping] Amyloid beta A4 precursor protein-binding family A member 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007399 [nervous system development] GO:0008021 [synaptic vesicle] GO:0015031 [protein transport] Show all	749 aa 82.5 kDa	No	0