Expression of RNF19A in cancer - Summary

CANCER ATLAS

Gene description

Ring finger protein 19A, RBR E3 ubiquitin protein ligase

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA023652	CAB011455

GENE INFORMATION
Gene name	RNF19A (HGNC Symbol)
Synonyms	DKFZp566B1346, dorfin, RNF19
Description	Ring finger protein 19A, RBR E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ring between ring fingers (RBR) protein family, and the encoded protein contains two RING-finger motifs and an in between RING fingers motif. This protein is an E3 ubiquitin ligase that is localized to Lewy bodies, and ubiquitylates synphilin-1, which is an interacting protein of alpha synuclein in neurons. The encoded protein may be involved in amyotrophic lateral sclerosis and Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Chromosome	8
Cytoband	q22.2
Chromosome location (bp)	100257059 - 100410015
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000034677 (version 83.38)
Entrez gene	25897
UniProt	Q9NV58 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NV58
Antibodypedia	RNF19A antibodies

PROTEIN BROWSER

RNF19A-001	RNF19A-002	RNF19A-003	RNF19A-004	RNF19A-009	RNF19A-010	RNF19A-012	RNF19A-015	RNF19A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RNF19A-001 ENSP00000342667 ENST00000341084	Q9NV58 [Direct mapping] E3 ubiquitin-protein ligase RNF19A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0000151 [ubiquitin ligase complex] GO:0000209 [protein polyubiquitination] GO:0000226 [microtubule cytoskeleton organization] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0016874 [ligase activity] GO:0031624 [ubiquitin conjugating enzyme binding] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] Show all	838 aa 90.7 kDa	No	2
RNF19A-002 ENSP00000429161 ENST00000517584	A0A0C4DGD6 [Direct mapping] E3 ubiquitin-protein ligase RNF19A Show all	Predicted intracellular proteins Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0016567 [protein ubiquitination] Show all	58 aa 6.5 kDa	No	0
RNF19A-003 ENSP00000428968 ENST00000519449	Q9NV58 [Direct mapping] E3 ubiquitin-protein ligase RNF19A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0000151 [ubiquitin ligase complex] GO:0000209 [protein polyubiquitination] GO:0000226 [microtubule cytoskeleton organization] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0016874 [ligase activity] GO:0031624 [ubiquitin conjugating enzyme binding] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] Show all	838 aa 90.7 kDa	No	2
RNF19A-004 ENSP00000397305 ENST00000432381	A3KCU8 [Direct mapping] E3 ubiquitin-protein ligase RNF19A; RING finger protein 19 isoform Show all	Predicted intracellular proteins Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0016567 [protein ubiquitination] Show all	89 aa 10 kDa	No	0
RNF19A-009 ENSP00000431077 ENST00000519527	E7ETB2 [Direct mapping] E3 ubiquitin-protein ligase RNF19A Show all	Predicted intracellular proteins Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0016567 [protein ubiquitination] Show all	165 aa 18.5 kDa	No	0
RNF19A-010 ENSP00000429841 ENST00000522369	E7EQ63 [Direct mapping] E3 ubiquitin-protein ligase RNF19A Show all	Predicted intracellular proteins Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0016567 [protein ubiquitination] Show all	113 aa 12.5 kDa	No	0
RNF19A-012 ENSP00000429549 ENST00000523167	E7EQV8 [Direct mapping] E3 ubiquitin-protein ligase RNF19A Show all	Predicted intracellular proteins Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0016567 [protein ubiquitination] Show all	156 aa 17.4 kDa	No	0
RNF19A-015 ENSP00000430553 ENST00000523481	E5RJH6 [Direct mapping] E3 ubiquitin-protein ligase RNF19A Show all	Predicted intracellular proteins Show all		15 aa 1.8 kDa	No	0
RNF19A-201 ENSP00000480369 ENST00000616528	Q9NV58 [Direct mapping] E3 ubiquitin-protein ligase RNF19A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0000151 [ubiquitin ligase complex] GO:0000209 [protein polyubiquitination] GO:0000226 [microtubule cytoskeleton organization] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0016874 [ligase activity] GO:0031624 [ubiquitin conjugating enzyme binding] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] Show all	838 aa 90.7 kDa	No	2