Cell atlas - DAPK2 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

DAPK2

TISSUE

premium

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus
	Vesicles

Human cell
	Golgi Apparatus
	Vesicles

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	DAPK2
Gene description	Death-associated protein kinase 2
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus & vesicles.
RNA cell category	Cell line enhanced (HMC-1)
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (approved), Vesicles (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA071581
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HMC-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus & vesicles.

Main location

Golgi apparatus (approved), Vesicles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA071581	HaCaT	Golgi apparatus
	HPA071581	HaCaT	Vesicles
	HPA071581	MCF7	Golgi apparatus
	HPA071581	U-2 OS	No staining

GENE INFORMATION
Gene name	DAPK2 (HGNC Symbol)
Synonyms	DRP-1, MGC119312
Description	Death-associated protein kinase 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q22.31
Chromosome location (bp)	63907036 - 64072033
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000035664 (version 83.38)
Entrez gene	23604
UniProt	Q9UIK4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UIK4
Antibodypedia	DAPK2 antibodies

PROTEIN BROWSER

DAPK2-001	DAPK2-003	DAPK2-007	DAPK2-201	DAPK2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DAPK2-001 ENSP00000408277 ENST00000457488	Q9UIK4 [Direct mapping] Death-associated protein kinase 2 A0A024R603 [Target identity:100%; Query identity:100%] Death-associated protein kinase 2, isoform CRA_b Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0010506 [regulation of autophagy] GO:0031410 [cytoplasmic vesicle] GO:0034423 [autophagosome lumen] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043276 [anoikis] GO:0046777 [protein autophosphorylation] GO:0090023 [positive regulation of neutrophil chemotaxis] GO:2000424 [positive regulation of eosinophil chemotaxis] GO:2001242 [regulation of intrinsic apoptotic signaling pathway] Show all	370 aa 42.9 kDa	No	1
DAPK2-003 ENSP00000484390 ENST00000612884	Q9UIK4 [Direct mapping] Death-associated protein kinase 2 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0010506 [regulation of autophagy] GO:0031410 [cytoplasmic vesicle] GO:0034423 [autophagosome lumen] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043276 [anoikis] GO:0046777 [protein autophosphorylation] GO:0090023 [positive regulation of neutrophil chemotaxis] GO:2000424 [positive regulation of eosinophil chemotaxis] GO:2001242 [regulation of intrinsic apoptotic signaling pathway] Show all	488 aa 55.9 kDa	No	1
DAPK2-007 ENSP00000452970 ENST00000559306	H0YKW8 [Direct mapping] Death-associated protein kinase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	81 aa 9.4 kDa	No	0
DAPK2-201 ENSP00000261891 ENST00000261891	Q9UIK4 [Direct mapping] Death-associated protein kinase 2 A0A024R603 [Target identity:100%; Query identity:100%] Death-associated protein kinase 2, isoform CRA_b Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0010506 [regulation of autophagy] GO:0031410 [cytoplasmic vesicle] GO:0034423 [autophagosome lumen] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043276 [anoikis] GO:0046777 [protein autophosphorylation] GO:0090023 [positive regulation of neutrophil chemotaxis] GO:2000424 [positive regulation of eosinophil chemotaxis] GO:2001242 [regulation of intrinsic apoptotic signaling pathway] Show all	370 aa 42.9 kDa	No	1
DAPK2-202 ENSP00000453235 ENST00000558069	Q9UIK4 [Direct mapping] Death-associated protein kinase 2 A0A0A6YYK9 [Direct mapping] Death-associated protein kinase 2 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0010506 [regulation of autophagy] GO:0031410 [cytoplasmic vesicle] GO:0034423 [autophagosome lumen] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043276 [anoikis] GO:0046777 [protein autophosphorylation] GO:0090023 [positive regulation of neutrophil chemotaxis] GO:2000424 [positive regulation of eosinophil chemotaxis] GO:2001242 [regulation of intrinsic apoptotic signaling pathway] Show all	488 aa 55.9 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.