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RFC1

CANCER ATLAS

Gene description

 Replication factor C (activator 1) 1, 145kDa

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB009520

Tissue

Cancer staining

Protein
expression of
normal tissue
Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue
Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

 Strong nuclear positivity was observed in several gliomas. Moderate nuclear and cytoplasmic staining was displayed in several breast, colorectal, endometrial, lung and liver cancers as well as a few cases of other cancers. Remaining cancer cells were weakly stained or negative.

GENE INFORMATION

Gene name

 RFC1 (HGNC Symbol)

Synonyms

 A1, MHCBFB, PO-GA, RFC140

Description

 Replication factor C (activator 1) 1, 145kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011]

Chromosome

 4

Cytoband

 p14

Chromosome location (bp)

 39287456 - 39366375

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000035928 (version 83.38)

Entrez gene

 5981

UniProt

 P35251 (UniProt - Evidence at protein level)

neXtProt

 NX_P35251

Antibodypedia

 RFC1 antibodies

PROTEIN BROWSER
RFC1-001
RFC1-003
RFC1-009
RFC1-015
RFC1-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RFC1-001
ENSP00000371321
ENST00000381897
P35251 [Direct mapping]
Replication factor C subunit 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0003677 [DNA binding]
GO:0003689 [DNA clamp loader activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005663 [DNA replication factor C complex]
GO:0005794 [Golgi apparatus]
GO:0006260 [DNA replication]
GO:0006261 [DNA-dependent DNA replication]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007004 [telomere maintenance via telomerase]
GO:0008047 [enzyme activator activity]
GO:0019985 [translesion synthesis]
GO:0030054 [cell junction]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0042276 [error-prone translesion synthesis]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0043085 [positive regulation of catalytic activity]
GO:0070062 [extracellular exosome]
GO:0070911 [global genome nucleotide-excision repair]
GO:0070987 [error-free translesion synthesis]
Show all
 1148 aa
128.3 kDa 		No 0
RFC1-003
ENSP00000422740
ENST00000503784
D6RAD2 [Direct mapping]
Replication factor C subunit 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
Show all
 132 aa
15 kDa 		No 0
RFC1-009
ENSP00000422129
ENST00000504554
H0Y8U4 [Direct mapping]
Replication factor C subunit 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0030054 [cell junction]
Show all
 187 aa
20.3 kDa 		No 0
RFC1-015
ENSP00000424713
ENST00000514572
H0Y9P8 [Direct mapping]
Replication factor C subunit 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003689 [DNA clamp loader activity]
GO:0005524 [ATP binding]
GO:0005663 [DNA replication factor C complex]
GO:0006260 [DNA replication]
Show all
 101 aa
11.4 kDa 		No 0
RFC1-017
ENSP00000261424
ENST00000349703
P35251 [Direct mapping]
Replication factor C subunit 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0003677 [DNA binding]
GO:0003689 [DNA clamp loader activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005663 [DNA replication factor C complex]
GO:0005794 [Golgi apparatus]
GO:0006260 [DNA replication]
GO:0006261 [DNA-dependent DNA replication]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007004 [telomere maintenance via telomerase]
GO:0008047 [enzyme activator activity]
GO:0019985 [translesion synthesis]
GO:0030054 [cell junction]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0042276 [error-prone translesion synthesis]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0043085 [positive regulation of catalytic activity]
GO:0070062 [extracellular exosome]
GO:0070911 [global genome nucleotide-excision repair]
GO:0070987 [error-free translesion synthesis]
Show all
 1147 aa
128.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.