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CUL3

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GENERAL INFORMATION

Gene name

 CUL3

Gene description

 Cullin 3

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CUL3

Synonyms

Description

 Cullin 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Chromosome

 2

Cytoband

 q36.2

Chromosome location (bp)

 224470150 - 224585397

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000036257 (version 83.38)

Entrez gene

 8452

UniProt

 Q13618 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13618

Antibodypedia

 CUL3 antibodies

PROTEIN BROWSER
CUL3-001
CUL3-002
CUL3-003
CUL3-006
CUL3-011
CUL3-201
CUL3-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CUL3-001
ENSP00000264414
ENST00000264414
Q13618 [Direct mapping]
Cullin-3
A0A024R475 [Target identity:100%; Query identity:100%]
Cullin 3, isoform CRA_a
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0000902 [cell morphogenesis]
GO:0001701 [in utero embryonic development]
GO:0001831 [trophectodermal cellular morphogenesis]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005827 [polar microtubule]
GO:0005829 [cytosol]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006513 [protein monoubiquitination]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007050 [cell cycle arrest]
GO:0007080 [mitotic metaphase plate congression]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007369 [gastrulation]
GO:0007411 [axon guidance]
GO:0008054 [negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016477 [cell migration]
GO:0016567 [protein ubiquitination]
GO:0017145 [stem cell division]
GO:0030332 [cyclin binding]
GO:0031208 [POZ domain binding]
GO:0031461 [cullin-RING ubiquitin ligase complex]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032467 [positive regulation of cytokinesis]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0040016 [embryonic cleavage]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0043149 [stress fiber assembly]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044346 [fibroblast apoptotic process]
GO:0045087 [innate immune response]
GO:0045842 [positive regulation of mitotic metaphase/anaphase transition]
GO:0046982 [protein heterodimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048208 [COPII vesicle coating]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0072576 [liver morphogenesis]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0097193 [intrinsic apoptotic signaling pathway]
Show all
 768 aa
88.9 kDa 		No 0
CUL3-002
ENSP00000387200
ENST00000409096
Q13618 [Direct mapping]
Cullin-3
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000209 [protein polyubiquitination]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005827 [polar microtubule]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006513 [protein monoubiquitination]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007050 [cell cycle arrest]
GO:0007080 [mitotic metaphase plate congression]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008054 [negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0016567 [protein ubiquitination]
GO:0017145 [stem cell division]
GO:0031208 [POZ domain binding]
GO:0031461 [cullin-RING ubiquitin ligase complex]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032467 [positive regulation of cytokinesis]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0040016 [embryonic cleavage]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043149 [stress fiber assembly]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0045842 [positive regulation of mitotic metaphase/anaphase transition]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048208 [COPII vesicle coating]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0097193 [intrinsic apoptotic signaling pathway]
Show all
 744 aa
86.2 kDa 		No 0
CUL3-003
ENSP00000386525
ENST00000409777
Q13618 [Direct mapping]
Cullin-3
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000209 [protein polyubiquitination]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005827 [polar microtubule]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006513 [protein monoubiquitination]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007050 [cell cycle arrest]
GO:0007080 [mitotic metaphase plate congression]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008054 [negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0016567 [protein ubiquitination]
GO:0017145 [stem cell division]
GO:0031208 [POZ domain binding]
GO:0031461 [cullin-RING ubiquitin ligase complex]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032467 [positive regulation of cytokinesis]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0040016 [embryonic cleavage]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043149 [stress fiber assembly]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0045842 [positive regulation of mitotic metaphase/anaphase transition]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048208 [COPII vesicle coating]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0097193 [intrinsic apoptotic signaling pathway]
Show all
 744 aa
86.2 kDa 		No 0
CUL3-006
ENSP00000400935
ENST00000436172
H7C1L6 [Direct mapping]
Cullin-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
Show all
 192 aa
22.5 kDa 		No 0
CUL3-011
ENSP00000410575
ENST00000451538
H7C399 [Direct mapping]
Cullin-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0031461 [cullin-RING ubiquitin ligase complex]
GO:0031625 [ubiquitin protein ligase binding]
Show all
 111 aa
12.5 kDa 		No 0
CUL3-201
ENSP00000343601
ENST00000344951
Q13618 [Direct mapping]
Cullin-3
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000209 [protein polyubiquitination]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005827 [polar microtubule]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006513 [protein monoubiquitination]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007050 [cell cycle arrest]
GO:0007080 [mitotic metaphase plate congression]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008054 [negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0016567 [protein ubiquitination]
GO:0017145 [stem cell division]
GO:0031208 [POZ domain binding]
GO:0031461 [cullin-RING ubiquitin ligase complex]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032467 [positive regulation of cytokinesis]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0040016 [embryonic cleavage]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043149 [stress fiber assembly]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0045842 [positive regulation of mitotic metaphase/anaphase transition]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048208 [COPII vesicle coating]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0097193 [intrinsic apoptotic signaling pathway]
Show all
 702 aa
81.1 kDa 		No 0
CUL3-202
ENSP00000477851
ENST00000617432
A0A087WTG3 [Direct mapping]
Cullin-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0031461 [cullin-RING ubiquitin ligase complex]
GO:0031625 [ubiquitin protein ligase binding]
Show all
 342 aa
39.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.