Expression of OTC in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Ornithine carbamoyltransferase

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA000243	HPA000570

GENE INFORMATION
Gene name	OTC
Synonyms
Description	Ornithine carbamoyltransferase (HGNC Symbol)
Entrez gene summary	This nuclear gene encodes a mitochondrial matrix enzyme. Missense, nonsense, and frameshift mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia. Since the gene for this enzyme maps close to that for Duchenne muscular dystrophy, it may play a role in that disease also. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	p11.4
Chromosome location (bp)	38352545 - 38421450
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000036473 (version 83.38)
Entrez gene	5009
UniProt	P00480 (UniProt - Evidence at protein level)
neXtProt	NX_P00480
Antibodypedia	OTC antibodies

PROTEIN BROWSER

OTC-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OTC-001 ENSP00000039007 ENST00000039007	P00480 [Direct mapping] Ornithine carbamoyltransferase, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000050 [urea cycle] GO:0001889 [liver development] GO:0004585 [ornithine carbamoyltransferase activity] GO:0005543 [phospholipid binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005759 [mitochondrial matrix] GO:0006520 [cellular amino acid metabolic process] GO:0006591 [ornithine metabolic process] GO:0006593 [ornithine catabolic process] GO:0006595 [polyamine metabolic process] GO:0007494 [midgut development] GO:0010043 [response to zinc ion] GO:0016597 [amino acid binding] GO:0016743 [carboxyl- or carbamoyltransferase activity] GO:0019240 [citrulline biosynthetic process] GO:0031667 [response to nutrient levels] GO:0032868 [response to insulin] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042301 [phosphate ion binding] GO:0042450 [arginine biosynthetic process via ornithine] GO:0042493 [response to drug] GO:0044281 [small molecule metabolic process] GO:0055081 [anion homeostasis] GO:0070207 [protein homotrimerization] GO:0070781 [response to biotin] GO:0097272 [ammonia homeostasis] Show all	354 aa 39.9 kDa	No	0