Tissue expression of FLT4 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	FLT4
Gene description	Fms-related tyrosine kinase 4
Protein class	Cancer-related genes Disease related genes Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins RAS pathway related proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Tissue enhanced (placenta)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (placenta)

GENE INFORMATION
Gene name	FLT4 (HGNC Symbol)
Synonyms	PCL, VEGFR3
Description	Fms-related tyrosine kinase 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q35.3
Chromosome location (bp)	180601506 - 180649624
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000037280 (version 83.38)
Entrez gene	2324
UniProt	P35916 (UniProt - Evidence at protein level)
neXtProt	NX_P35916
Antibodypedia	FLT4 antibodies

PROTEIN BROWSER

FLT4-001	FLT4-002	FLT4-003	FLT4-008	FLT4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FLT4-001 ENSP00000261937 ENST00000261937	P35916 [Direct mapping] Vascular endothelial growth factor receptor 3 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0001944 [vasculature development] GO:0001945 [lymph vessel development] GO:0001946 [lymphangiogenesis] GO:0002040 [sprouting angiogenesis] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005021 [vascular endothelial growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0010575 [positive regulation of vascular endothelial growth factor production] GO:0010595 [positive regulation of endothelial cell migration] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019838 [growth factor binding] GO:0019903 [protein phosphatase binding] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0038084 [vascular endothelial growth factor signaling pathway] GO:0043066 [negative regulation of apoptotic process] GO:0043235 [receptor complex] GO:0043410 [positive regulation of MAPK cascade] GO:0046330 [positive regulation of JNK cascade] GO:0046777 [protein autophosphorylation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048514 [blood vessel morphogenesis] GO:0060312 [regulation of blood vessel remodeling] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0090037 [positive regulation of protein kinase C signaling] Show all	1363 aa 152.8 kDa	Yes	1
FLT4-002 ENSP00000377016 ENST00000393347	P35916 [Direct mapping] Vascular endothelial growth factor receptor 3 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0001944 [vasculature development] GO:0001945 [lymph vessel development] GO:0001946 [lymphangiogenesis] GO:0002040 [sprouting angiogenesis] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005021 [vascular endothelial growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0010575 [positive regulation of vascular endothelial growth factor production] GO:0010595 [positive regulation of endothelial cell migration] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019838 [growth factor binding] GO:0019903 [protein phosphatase binding] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0038084 [vascular endothelial growth factor signaling pathway] GO:0043066 [negative regulation of apoptotic process] GO:0043235 [receptor complex] GO:0043410 [positive regulation of MAPK cascade] GO:0046330 [positive regulation of JNK cascade] GO:0046777 [protein autophosphorylation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048514 [blood vessel morphogenesis] GO:0060312 [regulation of blood vessel remodeling] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0090037 [positive regulation of protein kinase C signaling] Show all	1298 aa 145.6 kDa	Yes	1
FLT4-003 ENSP00000426057 ENST00000502649	E9PD35 [Direct mapping] Receptor protein-tyrosine kinase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005021 [vascular endothelial growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0038084 [vascular endothelial growth factor signaling pathway] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] Show all	1306 aa 146.5 kDa	Yes	1
FLT4-008 ENSP00000421535 ENST00000512795	D6RFF2 [Direct mapping] Vascular endothelial growth factor receptor 3 Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005021 [vascular endothelial growth factor-activated receptor activity] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0038084 [vascular endothelial growth factor signaling pathway] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] Show all	142 aa 16.2 kDa	No	0
FLT4-201 ENSP00000481134 ENST00000619105	B5A927 [Direct mapping] Soluble VEGFR3 variant 2; Vascular endothelial growth factor receptor 3 Show all	MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005021 [vascular endothelial growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0038084 [vascular endothelial growth factor signaling pathway] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] Show all	295 aa 33 kDa	Yes	0