Cell atlas - METTL1 - The Human Protein Atlas

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METTL1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	METTL1
Gene description	Methyltransferase like 1
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus.
RNA cell category	Cell line enriched (RH-30)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA020914 , HPA050450
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (RH-30) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus.

Main location

Nucleus (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA020914	A-431	Nucleoplasm
HPA020914	A-431	Cytosol
HPA020914	U-2 OS	Nucleoplasm
HPA020914	U-2 OS	Cytosol
HPA020914	U-251 MG	Nucleoplasm
HPA050450	A-431	Nucleus
HPA050450	PC-3	Nucleus
HPA050450	PC-3	Nucleoli
HPA050450	U-2 OS	Nucleus

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000006732 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA050450	NIH 3T3	No staining

GENE INFORMATION
Gene name	METTL1 (HGNC Symbol)
Synonyms	C12orf1, TRM8, TRMT8
Description	Methyltransferase like 1 (HGNC Symbol)
Entrez gene summary	This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q14.1
Chromosome location (bp)	57768471 - 57772793
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000037897 (version 83.38)
Entrez gene	4234
UniProt	Q9UBP6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBP6
Antibodypedia	METTL1 antibodies

PROTEIN BROWSER

METTL1-001	METTL1-002	METTL1-007	METTL1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
METTL1-001 ENSP00000314441 ENST00000324871	Q9UBP6 [Direct mapping] tRNA (guanine-N(7)-)-methyltransferase Show all	Enzymes ENZYME proteins Transferases THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006400 [tRNA modification] GO:0008033 [tRNA processing] GO:0008176 [tRNA (guanine-N7-)-methyltransferase activity] GO:0010467 [gene expression] GO:0030488 [tRNA methylation] GO:0036265 [RNA (guanine-N7)-methylation] GO:0043527 [tRNA methyltransferase complex] Show all	276 aa 31.5 kDa	No	0
METTL1-002 ENSP00000257848 ENST00000257848	Q9UBP6 [Direct mapping] tRNA (guanine-N(7)-)-methyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006400 [tRNA modification] GO:0008033 [tRNA processing] GO:0008176 [tRNA (guanine-N7-)-methyltransferase activity] GO:0010467 [gene expression] GO:0030488 [tRNA methylation] GO:0036265 [RNA (guanine-N7)-methylation] GO:0043527 [tRNA methyltransferase complex] Show all	155 aa 17.4 kDa	No	0
METTL1-007 ENSP00000449397 ENST00000548504	H0YIH0 [Direct mapping] tRNA (guanine-N(7)-)-methyltransferase Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006400 [tRNA modification] GO:0008176 [tRNA (guanine-N7-)-methyltransferase activity] GO:0030488 [tRNA methylation] GO:0036265 [RNA (guanine-N7)-methylation] GO:0043527 [tRNA methyltransferase complex] Show all	124 aa 14 kDa	No	0
METTL1-008 ENSP00000447838 ENST00000547653	H0YHU4 [Direct mapping] tRNA (guanine-N(7)-)-methyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006400 [tRNA modification] GO:0008176 [tRNA (guanine-N7-)-methyltransferase activity] GO:0030488 [tRNA methylation] GO:0036265 [RNA (guanine-N7)-methylation] GO:0043527 [tRNA methyltransferase complex] Show all	63 aa 7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.