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PI4K2B

GENERAL INFORMATION

Gene name

 PI4K2B

Gene description

 Phosphatidylinositol 4-kinase type 2 beta

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression. Additional membranous expression in intestinal tract.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 1 antibody.
HPA004099
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PI4K2B (HGNC Symbol)

Synonyms

 FLJ11105, PI4KIIB, PIK42B

Description

 Phosphatidylinositol 4-kinase type 2 beta (HGNC Symbol)

Entrez gene summary

 Phosphatidylinositol 4-kinases (PI4Ks) phosphorylate phosphatidylinositol to generate phosphatidylinositol 4-phosphate (PIP), an immediate precursor of several important signaling and scaffolding molecules. PIP itself may also have direct functional and structural roles. PI4K2B is a primarily cytosolic PI4K that is recruited to membranes, where it stimulates phosphatidylinositol 4,5-bisphosphate synthesis (Wei et al., 2002 [PubMed 12324459]).[supplied by OMIM, Jun 2008]

Chromosome

 4

Cytoband

 p15.2

Chromosome location (bp)

 25233975 - 25279092

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000038210 (version 83.38)

Entrez gene

 55300

UniProt

 Q8TCG2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TCG2

Antibodypedia

 PI4K2B antibodies

PROTEIN BROWSER
PI4K2B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PI4K2B-001
ENSP00000264864
ENST00000264864
Q8TCG2 [Direct mapping]
Phosphatidylinositol 4-kinase type 2-beta
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004430 [1-phosphatidylinositol 4-kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0016020 [membrane]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0044281 [small molecule metabolic process]
GO:0046854 [phosphatidylinositol phosphorylation]
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 481 aa
54.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.