Cell atlas - MSR1 - The Human Protein Atlas

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MSR1

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	MSR1
Gene description	Macrophage scavenger receptor 1
Protein class	Cancer-related genes CD markers Disease related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Group enriched (BJ hTERT+, REH)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (BJ hTERT+, REH) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	MSR1 (HGNC Symbol)
Synonyms	CD204, SCARA1
Description	Macrophage scavenger receptor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	p22
Chromosome location (bp)	16107878 - 16567490
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000038945 (version 83.38)
Entrez gene	4481
UniProt	P21757 (UniProt - Evidence at protein level)
neXtProt	NX_P21757
Antibodypedia	MSR1 antibodies

PROTEIN BROWSER

MSR1-001	MSR1-002	MSR1-003	MSR1-004	MSR1-006	MSR1-007	MSR1-008	MSR1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MSR1-001 ENSP00000262101 ENST00000262101	P21757 [Direct mapping] Macrophage scavenger receptor types I and II Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0005581 [collagen trimer] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006898 [receptor-mediated endocytosis] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010886 [positive regulation of cholesterol storage] GO:0016020 [membrane] GO:0030169 [low-density lipoprotein particle binding] GO:0030301 [cholesterol transport] GO:0030666 [endocytic vesicle membrane] GO:0031410 [cytoplasmic vesicle] GO:0034362 [low-density lipoprotein particle] GO:0034381 [plasma lipoprotein particle clearance] GO:0042953 [lipoprotein transport] GO:0071407 [cellular response to organic cyclic compound] Show all	451 aa 49.8 kDa	No	1
MSR1-002 ENSP00000347430 ENST00000355282	P21757 [Direct mapping] Macrophage scavenger receptor types I and II Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0005581 [collagen trimer] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006898 [receptor-mediated endocytosis] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010886 [positive regulation of cholesterol storage] GO:0016020 [membrane] GO:0030169 [low-density lipoprotein particle binding] GO:0030301 [cholesterol transport] GO:0030666 [endocytic vesicle membrane] GO:0034362 [low-density lipoprotein particle] GO:0034381 [plasma lipoprotein particle clearance] Show all	388 aa 42.9 kDa	No	1
MSR1-003 ENSP00000371428 ENST00000381998	P21757 [Direct mapping] Macrophage scavenger receptor types I and II Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0005581 [collagen trimer] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006898 [receptor-mediated endocytosis] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010886 [positive regulation of cholesterol storage] GO:0016020 [membrane] GO:0030169 [low-density lipoprotein particle binding] GO:0030301 [cholesterol transport] GO:0030666 [endocytic vesicle membrane] GO:0034362 [low-density lipoprotein particle] GO:0034381 [plasma lipoprotein particle clearance] Show all	358 aa 39.6 kDa	No	1
MSR1-004 ENSP00000405453 ENST00000445506	B4DDJ5 [Direct mapping] Macrophage scavenger receptor types I and II; cDNA FLJ55770, highly similar to Macrophage scavenger receptor types I and II Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	469 aa 51.7 kDa	No	1
MSR1-006 ENSP00000430536 ENST00000522672	H0YBY2 [Direct mapping] Macrophage scavenger receptor types I and II Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] Show all	149 aa 15.9 kDa	No	0
MSR1-007 ENSP00000429498 ENST00000518026	E5RI91 [Direct mapping] Macrophage scavenger receptor types I and II Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		58 aa 6.5 kDa	No	0
MSR1-008 ENSP00000427905 ENST00000518960	E5RFW8 [Direct mapping] Macrophage scavenger receptor types I and II Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] Show all	64 aa 7.3 kDa	No	0
MSR1-201 ENSP00000262100 ENST00000350896	P21757 [Direct mapping] Macrophage scavenger receptor types I and II Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0005581 [collagen trimer] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006898 [receptor-mediated endocytosis] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010886 [positive regulation of cholesterol storage] GO:0016020 [membrane] GO:0030169 [low-density lipoprotein particle binding] GO:0030301 [cholesterol transport] GO:0030666 [endocytic vesicle membrane] GO:0034362 [low-density lipoprotein particle] GO:0034381 [plasma lipoprotein particle clearance] Show all	388 aa 42.9 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.