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A majority of malignant cells were negative. A few cases of breast, prostate, ovarian and cervical tumors displayed moderate cytoplasmic staining. Rare cases of renal cancers displayed distinct nuclear immunoreactivity.
Cancer tissues showed weak cytoplasmic staining or were negative.
GENE INFORMATION
Gene name
SOX30
Synonyms
Description
SRY (sex determining region Y)-box 30 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein acts as a transcriptional regulator when present in a complex with other proteins. It can activate p53 transcription to promote tumor cell apoptosis in lung cancer. The protein may be involved in the differentiation of developing male germ cells. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Apr 2015]
Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Protein evidence (Kim et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0031960 [response to corticosteroid] GO:0043565 [sequence-specific DNA binding]
