Cell atlas - RTN4R - The Human Protein Atlas

GENERAL INFORMATION
Gene name	RTN4R
Gene description	Reticulon 4 receptor
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the actin filaments & focal adhesion sites.
RNA cell category	Cell line enhanced (REH, SCLC-21H, NB-4)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported)
Additional location	In addition localized to the Actin filaments (approved), Focal adhesion sites (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. CAB012443
	SHOW MORE

ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (REH, SCLC-21H, NB-4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the actin filaments & focal adhesion sites.

Main location

Plasma membrane (supported)

Additional location

Actin filaments (approved), Focal adhesion sites (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
CAB012443	A-431	Plasma membrane
CAB012443	A-431	Actin filaments
CAB012443	U-2 OS	Plasma membrane
CAB012443	U-2 OS	Focal adhesion sites
CAB012443	U-251 MG	Focal adhesion sites

GENE INFORMATION
Gene name	RTN4R (HGNC Symbol)
Synonyms	NOGOR
Description	Reticulon 4 receptor (HGNC Symbol)
Entrez gene summary	This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q11.21
Chromosome location (bp)	20241415 - 20283246
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000040608 (version 83.38)
Entrez gene	65078
UniProt	Q9BZR6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BZR6
Antibodypedia	RTN4R antibodies

PROTEIN BROWSER

RTN4R-001	RTN4R-002	RTN4R-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RTN4R-001 ENSP00000043402 ENST00000043402	Q9BZR6 [Direct mapping] Reticulon-4 receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007409 [axonogenesis] GO:0009986 [cell surface] GO:0023041 [neuronal signal transduction] GO:0030426 [growth cone] GO:0030517 [negative regulation of axon extension] GO:0031225 [anchored component of membrane] GO:0038131 [neuregulin receptor activity] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0043547 [positive regulation of GTPase activity] GO:0044295 [axonal growth cone] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050770 [regulation of axonogenesis] GO:0050771 [negative regulation of axonogenesis] GO:0070062 [extracellular exosome] Show all	473 aa 50.7 kDa	Yes	1
RTN4R-002 ENSP00000396872 ENST00000416372	H7C0V4 [Direct mapping] Reticulon-4 receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	493 aa 53 kDa	Yes	1
RTN4R-003 ENSP00000403535 ENST00000425986	H7C215 [Direct mapping] Reticulon-4 receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	559 aa 59.4 kDa	No	1