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Most cancer tissues displayed moderate to strong immunoreactivity. Malignant cells in general were negative. Tumor stroma often showed distinct positivity.
Cancer tissues generally displayed weak to moderate immunoreactivity. A majority of pancreastic, gastric, liver, colorectal and prostate cancers were negative.
GENE INFORMATION
Gene name
TNC (HGNC Symbol)
Synonyms
DFNA56, HXB, MGC167029, TN
Description
Tenascin C (HGNC Symbol)
Entrez gene summary
This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]