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MED17

GENERAL INFORMATION

Gene name

 MED17

Gene description

 Mediator complex subunit 17

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MED17 (HGNC Symbol)

Synonyms

 CRSP6, CRSP77, DRIP80, TRAP80

Description

 Mediator complex subunit 17 (HGNC Symbol)

Entrez gene summary

 The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q21

Chromosome location (bp)

 93784227 - 93814695

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000042429 (version 83.38)

Entrez gene

 9440

UniProt

 Q9NVC6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NVC6

Antibodypedia

 MED17 antibodies

PROTEIN BROWSER
MED17-001
MED17-002
MED17-003
MED17-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MED17-001
ENSP00000251871
ENST00000251871
Q9NVC6 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 17
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0003712 [transcription cofactor activity]
GO:0003713 [transcription coactivator activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016567 [protein ubiquitination]
GO:0016592 [mediator complex]
GO:0019827 [stem cell population maintenance]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0030518 [intracellular steroid hormone receptor signaling pathway]
GO:0030521 [androgen receptor signaling pathway]
GO:0042809 [vitamin D receptor binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046966 [thyroid hormone receptor binding]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070847 [core mediator complex]
Show all
 651 aa
72.9 kDa 		No 0
MED17-002
ENSP00000434459
ENST00000530819
Q9NVC6 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 17
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0003712 [transcription cofactor activity]
GO:0003713 [transcription coactivator activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016592 [mediator complex]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0030518 [intracellular steroid hormone receptor signaling pathway]
GO:0030521 [androgen receptor signaling pathway]
GO:0042809 [vitamin D receptor binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046966 [thyroid hormone receptor binding]
GO:0070847 [core mediator complex]
Show all
 145 aa
16 kDa 		No 0
MED17-003
ENSP00000431524
ENST00000533359
E9PKQ4 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 17
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016592 [mediator complex]
Show all
 232 aa
25.9 kDa 		No 0
MED17-012
ENSP00000433626
ENST00000528786
E9PJZ4 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 17
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016592 [mediator complex]
Show all
 143 aa
16.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.