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AP2S1

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GENERAL INFORMATION

Gene name

 AP2S1

Gene description

 Adaptor-related protein complex 2, sigma 1 subunit

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 AP2S1 (HGNC Symbol)

Synonyms

 CLAPS2, FBH3, FBHOk, HHC3

Description

 Adaptor-related protein complex 2, sigma 1 subunit (HGNC Symbol)

Entrez gene summary

 One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

 19

Cytoband

 q13.32

Chromosome location (bp)

 46838136 - 46850992

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000042753 (version 83.38)

Entrez gene

 1175

UniProt

 P53680 (UniProt - Evidence at protein level)

neXtProt

 NX_P53680

Antibodypedia

 AP2S1 antibodies

PROTEIN BROWSER
AP2S1-001
AP2S1-002
AP2S1-003
AP2S1-004
AP2S1-005
AP2S1-007
AP2S1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AP2S1-001
ENSP00000263270
ENST00000263270
P53680 [Direct mapping]
AP-2 complex subunit sigma
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030100 [regulation of endocytosis]
GO:0030117 [membrane coat]
GO:0030122 [AP-2 adaptor complex]
GO:0030666 [endocytic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0035615 [clathrin adaptor activity]
GO:0036020 [endolysosome membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048268 [clathrin coat assembly]
GO:0050690 [regulation of defense response to virus by virus]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 142 aa
17 kDa 		No 0
AP2S1-002
ENSP00000470235
ENST00000597020
M0QZ21 [Direct mapping]
AP-2 complex subunit sigma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 122 aa
14.6 kDa 		No 0
AP2S1-003
ENSP00000470898
ENST00000601649
P53680 [Direct mapping]
AP-2 complex subunit sigma
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016032 [viral process]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030100 [regulation of endocytosis]
GO:0030122 [AP-2 adaptor complex]
GO:0030666 [endocytic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0035615 [clathrin adaptor activity]
GO:0036020 [endolysosome membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048268 [clathrin coat assembly]
GO:0050690 [regulation of defense response to virus by virus]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 104 aa
12.4 kDa 		No 0
AP2S1-004
ENSP00000471340
ENST00000599990
M0R0N4 [Direct mapping]
AP-2 complex subunit sigma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 144 aa
17.3 kDa 		No 0
AP2S1-005
ENSP00000470176
ENST00000601498
M0QYZ2 [Direct mapping]
AP-2 complex subunit sigma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 158 aa
18.9 kDa 		No 0
AP2S1-007
ENSP00000263271
ENST00000352203
X6R390 [Direct mapping]
AP-2 complex subunit sigma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 156 aa
18.4 kDa 		No 0
AP2S1-008
ENSP00000472080
ENST00000593442
M0R1S0 [Direct mapping]
AP-2 complex subunit sigma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 92 aa
11 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.