Cell atlas - ADAM28 - The Human Protein Atlas

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ADAM28

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Plasma membrane

Human cell
	Mitochondria
	Plasma Membrane

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GENERAL INFORMATION
Gene name	ADAM28
Gene description	ADAM metallopeptidase domain 28
Protein class	Enzymes Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the mitochondria.
RNA cell category	Cell line enriched (CAPAN-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported)
Additional location	In addition localized to the Mitochondria (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA074034
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (CAPAN-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the mitochondria.

Main location

Plasma membrane (supported)

Additional location

Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA074034	U-2 OS	Plasma membrane
	HPA074034	U-2 OS	Mitochondria

GENE INFORMATION
Gene name	ADAM28 (HGNC Symbol)
Synonyms	ADAM23, eMDCII, MDC-Lm, MDC-Ls
Description	ADAM metallopeptidase domain 28 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. This gene is present in a gene cluster with other members of the ADAM family on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Chromosome	8
Cytoband	p21.2
Chromosome location (bp)	24294040 - 24359018
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000042980 (version 83.38)
Entrez gene	10863
UniProt	Q9UKQ2 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UKQ2
Antibodypedia	ADAM28 antibodies

PROTEIN BROWSER

ADAM28-001	ADAM28-002	ADAM28-009	ADAM28-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAM28-001 ENSP00000265769 ENST00000265769	Q9UKQ2 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 28 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0007283 [spermatogenesis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	775 aa 87.1 kDa	Yes	1
ADAM28-002 ENSP00000393699 ENST00000437154	Q9UKQ2 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 28 Show all	Enzymes Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0007283 [spermatogenesis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	540 aa 61.2 kDa	Yes	0
ADAM28-009 ENSP00000430094 ENST00000518326	H0YBQ8 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 28 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	174 aa 19.2 kDa	No	2
ADAM28-011 ENSP00000429484 ENST00000521629	H0YBG8 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 28 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	387 aa 42.7 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.