Cell atlas - ZIC2 - The Human Protein Atlas

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ZIC2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ZIC2
Gene description	Zic family member 2
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear bodies.
RNA cell category	Cell line enhanced (SCLC-21H, AF22, NTERA-2, HEK 293)
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear bodies (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA055031
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, AF22, NTERA-2, HEK 293) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear bodies.

Main location

Nuclear bodies (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA055031	HEK 293	Nucleus
	HPA055031	HEK 293	Nuclear bodies
	HPA055031	U-2 OS	Nuclear bodies
	HPA055031	U-251 MG	Nuclear bodies

GENE INFORMATION
Gene name	ZIC2 (HGNC Symbol)
Synonyms	HPE5
Description	Zic family member 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13. [provided by RefSeq, Jul 2008]
Chromosome	13
Cytoband	q32.3
Chromosome location (bp)	99981772 - 99986773
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000043355 (version 83.38)
Entrez gene	7546
UniProt	O95409 (UniProt - Evidence at protein level)
neXtProt	NX_O95409
Antibodypedia	ZIC2 antibodies

PROTEIN BROWSER

ZIC2-001	ZIC2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZIC2-001 ENSP00000365514 ENST00000376335	O95409 [Direct mapping] Zinc finger protein ZIC 2 A0A024RDY6 [Target identity:100%; Query identity:100%] Zic family member 2 (Odd-paired homolog, Drosophila), isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001843 [neural tube closure] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0007399 [nervous system development] GO:0007417 [central nervous system development] GO:0007420 [brain development] GO:0007601 [visual perception] GO:0030154 [cell differentiation] GO:0031490 [chromatin DNA binding] GO:0044782 [cilium organization] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0048066 [developmental pigmentation] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:1900224 [positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry] Show all	532 aa 55 kDa	No	0
ZIC2-201 ENSP00000481510 ENST00000620342	A0A087WY47 [Direct mapping] Zinc finger protein ZIC 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	531 aa 54.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.