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Malignant tissues were often weak cytoplasmic stained. A few malignant gliomas and testicular cancers showed moderate intensity.
GENE INFORMATION
Gene name
EPHA3 (HGNC Symbol)
Synonyms
ETK, ETK1, HEK, HEK4, TYRO4
Description
EPH receptor A3 (HGNC Symbol)
Entrez gene summary
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005003 [ephrin receptor activity] GO:0005004 [GPI-linked ephrin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007155 [cell adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007411 [axon guidance] GO:0010717 [regulation of epithelial to mesenchymal transition] GO:0010976 [positive regulation of neuron projection development] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0032956 [regulation of actin cytoskeleton organization] GO:0043087 [regulation of GTPase activity] GO:0048013 [ephrin receptor signaling pathway] GO:0051893 [regulation of focal adhesion assembly] GO:0070507 [regulation of microtubule cytoskeleton organization] GO:0071300 [cellular response to retinoic acid] GO:0097155 [fasciculation of sensory neuron axon] GO:0097156 [fasciculation of motor neuron axon]
