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Moderate to strong nuclear immunoreactivity was exhibited in few melanomas, hepatocellular carcinomas, seminomas and squamous cell carcinomas along with rare urothelial cancers. A rare case of prostate cancer displayed moderate cytoplasmic staining. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
MAGEC2 (HGNC Symbol)
Synonyms
CT10, MAGE-C2, MAGEE1
Description
Melanoma antigen family C2 (HGNC Symbol)
Entrez gene summary
This gene is a member of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the other MAGEC genes are clustered on chromosome Xq26-q27. [provided by RefSeq, Oct 2009]
MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0031625 [ubiquitin protein ligase binding] GO:0044257 [cellular protein catabolic process] GO:0051443 [positive regulation of ubiquitin-protein transferase activity]
