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Malignant tissues displayed moderate to strong cytoplasmic immunoreactivity. Additional membranous staining was observed in colorectal and pancreatic cancers.
Malignant tissues displayed weak to moderate cytoplasmic positivity. A few cases of malignant gliomas and prostate cancers were strongly stained. Testicular, gastric and liver cancers were negative.
GENE INFORMATION
Gene name
WDR37 (HGNC Symbol)
Synonyms
KIAA0982
Description
WD repeat domain 37 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]