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CTPS2

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GENERAL INFORMATION

Gene name

 CTPS2

Gene description

 CTP synthase 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol & nucleoplasm.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved), Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA017437
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol & nucleoplasm.

Main location

 Nucleoplasm (approved), Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA017437 A-431 Nucleoplasm
HPA017437 U-2 OS Cytosol
HPA017437 U-251 MG Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 CTPS2

Synonyms

Description

 CTP synthase 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Chromosome

 X

Cytoband

 p22.2

Chromosome location (bp)

 16588003 - 16712936

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000047230 (version 83.38)

Entrez gene

 56474

UniProt

 Q9NRF8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NRF8

Antibodypedia

 CTPS2 antibodies

PROTEIN BROWSER
CTPS2-001
CTPS2-002
CTPS2-004
CTPS2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CTPS2-001
ENSP00000369590
ENST00000380241
Q9NRF8 [Direct mapping]
CTP synthase 2
A0A024RC00 [Target identity:100%; Query identity:100%]
CTP synthase
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Enzymes
   ENZYME proteins
   Ligase
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003883 [CTP synthase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006220 [pyrimidine nucleotide metabolic process]
GO:0006221 [pyrimidine nucleotide biosynthetic process]
GO:0006541 [glutamine metabolic process]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0044210 ['de novo' CTP biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 586 aa
65.7 kDa 		No 0
CTPS2-002
ENSP00000352222
ENST00000359276
Q9NRF8 [Direct mapping]
CTP synthase 2
A0A024RC00 [Target identity:100%; Query identity:100%]
CTP synthase
Show all
Enzymes
   ENZYME proteins
   Ligase
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003883 [CTP synthase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006220 [pyrimidine nucleotide metabolic process]
GO:0006221 [pyrimidine nucleotide biosynthetic process]
GO:0006541 [glutamine metabolic process]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0044210 ['de novo' CTP biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 586 aa
65.7 kDa 		No 0
CTPS2-004
ENSP00000400431
ENST00000455276
H0Y5S6 [Direct mapping]
CTP synthase 2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003883 [CTP synthase activity]
GO:0006221 [pyrimidine nucleotide biosynthetic process]
Show all
 132 aa
14.5 kDa 		No 0
CTPS2-201
ENSP00000401264
ENST00000443824
Q9NRF8 [Direct mapping]
CTP synthase 2
A0A024RC00 [Target identity:100%; Query identity:100%]
CTP synthase
Show all
Enzymes
   ENZYME proteins
   Ligase
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003883 [CTP synthase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006220 [pyrimidine nucleotide metabolic process]
GO:0006221 [pyrimidine nucleotide biosynthetic process]
GO:0006541 [glutamine metabolic process]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0044210 ['de novo' CTP biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 586 aa
65.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.