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ATP6V1H

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GENERAL INFORMATION

Gene name

 ATP6V1H

Gene description

 ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H

Protein class

 Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the actin filaments. In addition localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Actin filaments (approved)

Additional location

 In addition localized to the Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA023421
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the actin filaments. In addition localized to the cytosol.

Main location

 Actin filaments (approved)

Additional location

 Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA023421 A-431 Actin filaments
Cytosol
HPA023421 U-2 OS Actin filaments
HPA023421 U-251 MG Actin filaments
Cytosol

GENE INFORMATION

Gene name

 ATP6V1H (HGNC Symbol)

Synonyms

 CGI-11, SFD, SFDalpha, SFDbeta, VMA13

Description

 ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H (HGNC Symbol)

Entrez gene summary

 This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular organelles. V-ATPase-dependent organelle acidification is necessary for multiple processes including protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. The encoded protein is the regulatory H subunit of the V1 domain of V-ATPase, which is required for catalysis of ATP but not the assembly of V-ATPase. Decreased expression of this gene may play a role in the development of type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Chromosome

 8

Cytoband

 q11.23

Chromosome location (bp)

 53715557 - 53843558

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000047249 (version 83.38)

Entrez gene

 51606

UniProt

 Q9UI12 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UI12

Antibodypedia

 ATP6V1H antibodies

PROTEIN BROWSER
ATP6V1H-001
ATP6V1H-002
ATP6V1H-004
ATP6V1H-005
ATP6V1H-006
ATP6V1H-010
ATP6V1H-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP6V1H-001
ENSP00000347359
ENST00000355221
Q9UI12 [Direct mapping]
V-type proton ATPase subunit H
A0A024R7X3 [Target identity:100%; Query identity:100%]
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H, isoform CRA_b
Show all
Transporters
   Primary Active Transporters
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000221 [vacuolar proton-transporting V-type ATPase, V1 domain]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006879 [cellular iron ion homeostasis]
GO:0006897 [endocytosis]
GO:0007035 [vacuolar acidification]
GO:0008286 [insulin receptor signaling pathway]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016032 [viral process]
GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances]
GO:0016887 [ATPase activity]
GO:0030234 [enzyme regulator activity]
GO:0033572 [transferrin transport]
GO:0034220 [ion transmembrane transport]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050790 [regulation of catalytic activity]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0090382 [phagosome maturation]
Show all
 465 aa
54.2 kDa 		No 0
ATP6V1H-002
ENSP00000352522
ENST00000359530
Q9UI12 [Direct mapping]
V-type proton ATPase subunit H
A0A024R7U9 [Target identity:100%; Query identity:100%]
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H, isoform CRA_a
Show all
Transporters
   Primary Active Transporters
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000221 [vacuolar proton-transporting V-type ATPase, V1 domain]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006879 [cellular iron ion homeostasis]
GO:0006897 [endocytosis]
GO:0007035 [vacuolar acidification]
GO:0008286 [insulin receptor signaling pathway]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016032 [viral process]
GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances]
GO:0016887 [ATPase activity]
GO:0030234 [enzyme regulator activity]
GO:0033572 [transferrin transport]
GO:0034220 [ion transmembrane transport]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050790 [regulation of catalytic activity]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0090382 [phagosome maturation]
Show all
 483 aa
55.9 kDa 		No 0
ATP6V1H-004
ENSP00000429947
ENST00000520188
G3V126 [Direct mapping]
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H, isoform CRA_c; V-type proton ATPase subunit H
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000221 [vacuolar proton-transporting V-type ATPase, V1 domain]
GO:0005488 [binding]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
Show all
 443 aa
51.6 kDa 		No 0
ATP6V1H-005
ENSP00000379995
ENST00000396774
Q9UI12 [Direct mapping]
V-type proton ATPase subunit H
A0A024R7U9 [Target identity:100%; Query identity:100%]
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H, isoform CRA_a
Show all
Transporters
   Primary Active Transporters
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000221 [vacuolar proton-transporting V-type ATPase, V1 domain]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006879 [cellular iron ion homeostasis]
GO:0006897 [endocytosis]
GO:0007035 [vacuolar acidification]
GO:0008286 [insulin receptor signaling pathway]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016032 [viral process]
GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances]
GO:0016887 [ATPase activity]
GO:0030234 [enzyme regulator activity]
GO:0033572 [transferrin transport]
GO:0034220 [ion transmembrane transport]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050790 [regulation of catalytic activity]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0090382 [phagosome maturation]
Show all
 483 aa
55.9 kDa 		No 0
ATP6V1H-006
ENSP00000427835
ENST00000524234
E5RG49 [Direct mapping]
V-type proton ATPase subunit H
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000221 [vacuolar proton-transporting V-type ATPase, V1 domain]
GO:0005488 [binding]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
Show all
 101 aa
11.5 kDa 		No 0
ATP6V1H-010
ENSP00000429786
ENST00000521275
E5RHH0 [Direct mapping]
V-type proton ATPase subunit H
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000221 [vacuolar proton-transporting V-type ATPase, V1 domain]
GO:0005488 [binding]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
Show all
 102 aa
11.7 kDa 		No 0
ATP6V1H-201
ENSP00000487194
ENST00000630578
A0A0D9SG68 [Direct mapping]
V-type proton ATPase subunit H
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000221 [vacuolar proton-transporting V-type ATPase, V1 domain]
GO:0005488 [binding]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
Show all
 48 aa
5.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.