Cell atlas - XK - The Human Protein Atlas

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XK

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Nucleoplasm
	Vesicles

Human cell
	Mitochondria
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	XK
Gene description	X-linked Kx blood group
Protein class	Blood group antigen proteins Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria. In addition localized to the nucleoplasm & vesicles.
RNA cell category	Cell line enhanced (HEL, K-562)
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (approved)
Additional location	In addition localized to the Nucleoplasm (approved), Vesicles (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA019036
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEL, K-562) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria. In addition localized to the nucleoplasm & vesicles.

Main location

Mitochondria (approved)

Additional location

Nucleoplasm (approved), Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA019036	A-431	Nucleoplasm
	HPA019036	A-431	Mitochondria
	HPA019036	U-2 OS	Mitochondria	Intensity
	HPA019036	U-251 MG	Vesicles
	HPA019036	U-251 MG	Mitochondria

GENE INFORMATION
Gene name	XK (HGNC Symbol)
Synonyms	Kx, NA, NAC, X1k, XKR1
Description	X-linked Kx blood group (HGNC Symbol)
Entrez gene summary	This locus controls the synthesis of the Kell blood group 'precursor substance' (Kx). Mutations in this gene have been associated with McLeod syndrome, an X-linked, recessive disorder characterized by abnormalities in the neuromuscular and hematopoietic systems. The encoded protein has structural characteristics of prokaryotic and eukaryotic membrane transport proteins. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	p21.1
Chromosome location (bp)	37685759 - 37732130
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000047597 (version 83.38)
Entrez gene	7504
UniProt	P51811 (UniProt - Evidence at protein level)
neXtProt	NX_P51811
Antibodypedia	XK antibodies

PROTEIN BROWSER

XK-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
XK-001 ENSP00000367879 ENST00000378616	P51811 [Direct mapping] Membrane transport protein XK Show all	Blood group antigen proteins Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005623 [cell] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006865 [amino acid transport] GO:0006874 [cellular calcium ion homeostasis] GO:0008361 [regulation of cell size] GO:0010961 [cellular magnesium ion homeostasis] GO:0016021 [integral component of membrane] GO:0031133 [regulation of axon diameter] GO:0042552 [myelination] GO:0048741 [skeletal muscle fiber development] Show all	444 aa 50.9 kDa	Yes	8

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.