Cell atlas - WWC3 - The Human Protein Atlas

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WWC3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Actin filaments
	Cytosol

Human cell
	Actin Filaments
	Cytosol

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GENERAL INFORMATION
Gene name	WWC3
Gene description	WWC family member 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the actin filaments.
RNA cell category	Cell line enhanced (T-47d)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Additional location	In addition localized to the Actin filaments (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA039814
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (T-47d) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the actin filaments.

Main location

Cytosol (approved)

Additional location

Actin filaments (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA039814	A-431	Cytosol
	HPA039814	U-2 OS	Actin filaments
	HPA039814	U-2 OS	Cytosol
	HPA039814	U-251 MG	Cytosol

GENE INFORMATION
Gene name	WWC3 (HGNC Symbol)
Synonyms	BM042, KIAA1280
Description	WWC family member 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the WWC family of proteins, which also includes the WWC1 (KIBRA) gene product and the WWC2 gene product. The protein encoded by this gene includes a C2 domain, which is known to mediate homodimerization in the related WWC1 gene product. [provided by RefSeq, Sep 2011]
Chromosome	X
Cytoband	p22.2
Chromosome location (bp)	10015562 - 10144478
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000047644 (version 83.38)
Entrez gene	55841
UniProt	Q9ULE0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9ULE0
Antibodypedia	WWC3 antibodies

PROTEIN BROWSER

WWC3-001	WWC3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WWC3-001 ENSP00000370242 ENST00000380861	Q9ULE0 [Direct mapping] Protein WWC3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0019900 [kinase binding] GO:0032947 [protein complex scaffold] GO:0035331 [negative regulation of hippo signaling] GO:0046621 [negative regulation of organ growth] Show all	1092 aa 122.7 kDa	No	0
WWC3-201 ENSP00000399584 ENST00000454666	A0A0A0MSQ8 [Direct mapping] Protein WWC3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1216 aa 136.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.