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ARHGAP6

GENERAL INFORMATION

Gene name

 ARHGAP6

Gene description

 Rho GTPase activating protein 6

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (prostate, seminal vesicle)
GTEx:Mixed
FANTOM5:Tissue enhanced (seminal vesicle)

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression, most abundant in glandular cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA036779 , HPA064390
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (prostate, seminal vesicle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (seminal vesicle)

GENE INFORMATION

Gene name

 ARHGAP6 (HGNC Symbol)

Synonyms

 rhoGAPX-1

Description

 Rho GTPase activating protein 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 p22.2

Chromosome location (bp)

 11137543 - 11665701

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000047648 (version 83.38)

Entrez gene

 395

UniProt

 O43182 (UniProt - Evidence at protein level)

neXtProt

 NX_O43182

Antibodypedia

 ARHGAP6 antibodies

PROTEIN BROWSER
ARHGAP6-001
ARHGAP6-003
ARHGAP6-004
ARHGAP6-005
ARHGAP6-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGAP6-001
ENSP00000338967
ENST00000337414
O43182 [Direct mapping]
Rho GTPase-activating protein 6
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0007015 [actin filament organization]
GO:0007165 [signal transduction]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0009967 [positive regulation of signal transduction]
GO:0010518 [positive regulation of phospholipase activity]
GO:0015629 [actin cytoskeleton]
GO:0016004 [phospholipase activator activity]
GO:0017124 [SH3 domain binding]
GO:0030041 [actin filament polymerization]
GO:0043087 [regulation of GTPase activity]
GO:0043274 [phospholipase binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0048041 [focal adhesion assembly]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0051895 [negative regulation of focal adhesion assembly]
Show all
 974 aa
105.9 kDa 		Yes 0
ARHGAP6-003
ENSP00000370094
ENST00000380718
O43182 [Direct mapping]
Rho GTPase-activating protein 6
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0007165 [signal transduction]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0009967 [positive regulation of signal transduction]
GO:0010518 [positive regulation of phospholipase activity]
GO:0015629 [actin cytoskeleton]
GO:0016004 [phospholipase activator activity]
GO:0017124 [SH3 domain binding]
GO:0030041 [actin filament polymerization]
GO:0043274 [phospholipase binding]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0051895 [negative regulation of focal adhesion assembly]
Show all
 765 aa
83.9 kDa 		Yes 0
ARHGAP6-004
ENSP00000302312
ENST00000303025
O43182 [Direct mapping]
Rho GTPase-activating protein 6
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0007165 [signal transduction]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0009967 [positive regulation of signal transduction]
GO:0010518 [positive regulation of phospholipase activity]
GO:0015629 [actin cytoskeleton]
GO:0016004 [phospholipase activator activity]
GO:0017124 [SH3 domain binding]
GO:0030041 [actin filament polymerization]
GO:0043274 [phospholipase binding]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0051895 [negative regulation of focal adhesion assembly]
Show all
 771 aa
84.8 kDa 		No 0
ARHGAP6-005
ENSP00000370093
ENST00000380717
H7BYE6 [Direct mapping]
Rho GTPase-activating protein 6
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007165 [signal transduction]
Show all
 601 aa
67.3 kDa 		No 0
ARHGAP6-007
ENSP00000370112
ENST00000380736
O43182 [Direct mapping]
Rho GTPase-activating protein 6
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0007165 [signal transduction]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0009967 [positive regulation of signal transduction]
GO:0010518 [positive regulation of phospholipase activity]
GO:0015629 [actin cytoskeleton]
GO:0016004 [phospholipase activator activity]
GO:0017124 [SH3 domain binding]
GO:0030041 [actin filament polymerization]
GO:0043274 [phospholipase binding]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0051895 [negative regulation of focal adhesion assembly]
Show all
 771 aa
84.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.