Tissue expression of MAP4 - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MAP4

premium

TISSUE

premium

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MAP4
Gene description	Microtubule-associated protein 4
Protein class	FDA approved drug targets Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA038149 , HPA038150
	SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	MAP4
Synonyms
Description	Microtubule-associated protein 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	47850690 - 48089272
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000047849 (version 83.38)
Entrez gene	4134
UniProt	P27816 (UniProt - Evidence at protein level)
neXtProt	NX_P27816
Antibodypedia	MAP4 antibodies

PROTEIN BROWSER

MAP4-001	MAP4-003	MAP4-005	MAP4-006	MAP4-007	MAP4-009	MAP4-011	MAP4-012	MAP4-013	MAP4-014	MAP4-015	MAP4-019

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAP4-001 ENSP00000353375 ENST00000360240	P27816 [Direct mapping] Microtubule-associated protein 4 Show all	Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0007052 [mitotic spindle organization] GO:0008017 [microtubule binding] GO:0015630 [microtubule cytoskeleton] GO:0015631 [tubulin binding] GO:0031175 [neuron projection development] GO:0043005 [neuron projection] GO:0044822 [poly(A) RNA binding] GO:0051012 [microtubule sliding] GO:0051294 [establishment of spindle orientation] GO:0051301 [cell division] GO:0070062 [extracellular exosome] GO:0072686 [mitotic spindle] GO:0097481 [neuronal postsynaptic density] Show all	1152 aa 121 kDa	No	0
MAP4-003 ENSP00000397414 ENST00000439356	P27816 [Direct mapping] Microtubule-associated protein 4 Show all	Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0007052 [mitotic spindle organization] GO:0008017 [microtubule binding] GO:0015630 [microtubule cytoskeleton] GO:0031175 [neuron projection development] GO:0043005 [neuron projection] GO:0044822 [poly(A) RNA binding] GO:0051012 [microtubule sliding] GO:0051294 [establishment of spindle orientation] GO:0051301 [cell division] GO:0070062 [extracellular exosome] GO:0072686 [mitotic spindle] Show all	99 aa 10.4 kDa	No	0
MAP4-005 ENSP00000407602 ENST00000426837	E7EVA0 [Direct mapping] Microtubule-associated protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0005886 [plasma membrane] GO:0008017 [microtubule binding] GO:0015630 [microtubule cytoskeleton] GO:0015631 [tubulin binding] Show all	2297 aa 245.4 kDa	No	0
MAP4-006 ENSP00000379083 ENST00000395734	P27816 [Direct mapping] Microtubule-associated protein 4 Show all	Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0007052 [mitotic spindle organization] GO:0008017 [microtubule binding] GO:0015630 [microtubule cytoskeleton] GO:0015631 [tubulin binding] GO:0031175 [neuron projection development] GO:0043005 [neuron projection] GO:0044822 [poly(A) RNA binding] GO:0051012 [microtubule sliding] GO:0051294 [establishment of spindle orientation] GO:0051301 [cell division] GO:0070062 [extracellular exosome] GO:0072686 [mitotic spindle] Show all	1135 aa 120 kDa	No	0
MAP4-007 ENSP00000402767 ENST00000434267	P27816 [Direct mapping] Microtubule-associated protein 4 Show all	Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0007052 [mitotic spindle organization] GO:0008017 [microtubule binding] GO:0015630 [microtubule cytoskeleton] GO:0031175 [neuron projection development] GO:0043005 [neuron projection] GO:0044822 [poly(A) RNA binding] GO:0051012 [microtubule sliding] GO:0051294 [establishment of spindle orientation] GO:0051301 [cell division] GO:0070062 [extracellular exosome] GO:0072686 [mitotic spindle] Show all	99 aa 10.4 kDa	No	0
MAP4-009 ENSP00000373242 ENST00000383736	B5MEG9 [Direct mapping] Microtubule-associated protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008017 [microtubule binding] Show all	761 aa 80.4 kDa	No	0
MAP4-011 ENSP00000416743 ENST00000429422	H7C4C5 [Direct mapping] Microtubule-associated protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0008017 [microtubule binding] GO:0015631 [tubulin binding] Show all	493 aa 50.9 kDa	No	0
MAP4-012 ENSP00000334770 ENST00000335271	H0Y2V1 [Direct mapping] Microtubule-associated protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0008017 [microtubule binding] GO:0015631 [tubulin binding] Show all	463 aa 48.6 kDa	No	0
MAP4-013 ENSP00000409731 ENST00000420772	F8W9U4 [Direct mapping] Microtubule-associated protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0008017 [microtubule binding] GO:0015631 [tubulin binding] Show all	828 aa 88.3 kDa	No	0
MAP4-014 ENSP00000487698 ENST00000468075		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		76 aa 8.2 kDa	No	0
MAP4-015 ENSP00000415689 ENST00000423088	H7C456 [Direct mapping] Microtubule-associated protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008017 [microtubule binding] Show all	283 aa 30.7 kDa	No	0
MAP4-019 ENSP00000487797 ENST00000633710		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		140 aa 15.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.