Cell atlas - USP28 - The Human Protein Atlas

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USP28

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	USP28
Gene description	Ubiquitin specific peptidase 28
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the nuclear bodies.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Nuclear bodies (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA006778
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the nuclear bodies.

Main location

Nucleoplasm (supported)

Additional location

Nuclear bodies (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA006778	A-431	Nucleoplasm
	HPA006778	U-2 OS	Nucleoplasm
	HPA006778	U-251 MG	Nucleoplasm
	HPA006778	U-251 MG	Nuclear bodies

GENE INFORMATION
Gene name	USP28 (HGNC Symbol)
Synonyms	KIAA1515
Description	Ubiquitin specific peptidase 28 (HGNC Symbol)
Entrez gene summary	The ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins and peptides. Enzymes that remove ubiquitin from ubiquitin-conjugated peptides, like USP28, affect the fate and degradation of intracellular proteins and are essential for maintenance of cell-free ubiquitin pools (Valero et al., 2001).[supplied by OMIM, Mar 2008]
Chromosome	11
Cytoband	q23.2
Chromosome location (bp)	113797874 - 113875570
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000048028 (version 83.38)
Entrez gene	57646
UniProt	Q96RU2 (UniProt - Evidence at protein level)
neXtProt	NX_Q96RU2
Antibodypedia	USP28 antibodies

PROTEIN BROWSER

USP28-001	USP28-002	USP28-004	USP28-006	USP28-007	USP28-008	USP28-009	USP28-012	USP28-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
USP28-001 ENSP00000003302 ENST00000003302	Q96RU2 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 28 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000077 [DNA damage checkpoint] GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006281 [DNA repair] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0008283 [cell proliferation] GO:0010212 [response to ionizing radiation] GO:0016579 [protein deubiquitination] GO:0034644 [cellular response to UV] GO:0036459 [ubiquitinyl hydrolase activity] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043234 [protein complex] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	1077 aa 122.5 kDa	No	0
USP28-002 ENSP00000445743 ENST00000537706	Q96RU2 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 28 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000077 [DNA damage checkpoint] GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006281 [DNA repair] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0008283 [cell proliferation] GO:0010212 [response to ionizing radiation] GO:0016579 [protein deubiquitination] GO:0034644 [cellular response to UV] GO:0036459 [ubiquitinyl hydrolase activity] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043234 [protein complex] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	583 aa 66.2 kDa	No	0
USP28-004 ENSP00000444991 ENST00000545540	B4E3L3 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	920 aa 105.8 kDa	No	0
USP28-006 ENSP00000442431 ENST00000544967	G3V1N5 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 28; Ubiquitin specific peptidase 28, isoform CRA_c Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	753 aa 86.3 kDa	No	0
USP28-007 ENSP00000446284 ENST00000540925	F5H2G4 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 28 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	77 aa 8.7 kDa	No	0
USP28-008 ENSP00000437450 ENST00000544750	F5H6Q3 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 28 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	46 aa 5.3 kDa	No	0
USP28-009 ENSP00000440799 ENST00000537642	H0YFX3 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 28 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	244 aa 27.8 kDa	No	0
USP28-012 ENSP00000442257 ENST00000538475	H0YG96 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 28 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	360 aa 41.9 kDa	No	0
USP28-014 ENSP00000440260 ENST00000538224	H0YFT9 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 28 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	194 aa 21.5 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.