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Malignant gliomas, non-Hogdkins lymphomas and several cases of malignant melanomas and basal cell carcinomas of skin exhibited moderate to strong nuclear immunoreactivity. A few colorectal and endometrial cancers showed moderate nuclear staining. Remaining tumors were mainly negative.
Many cases of lymphomas and gliomas showed moderate to strong nuclear immunoreactivity. Remaining cancer cells were in general negative.
GENE INFORMATION
Gene name
CELF2 (HGNC Symbol)
Synonyms
BRUNOL3, CUGBP2, Etr-3, NAPOR-2
Description
CUGBP, Elav-like family member 2 (HGNC Symbol)
Entrez gene summary
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]