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Several cases of liver, renal cancers along with a few cases of colorectal, stomach and pancreatic cancers showed weak to moderate cytoplasmic positivity. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
COL9A2 (HGNC Symbol)
Synonyms
EDM2, MED
Description
Collagen, type IX, alpha 2 (HGNC Symbol)
Entrez gene summary
This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. This chain is unusual in that, unlike the other two type IX alpha chains, it contains a covalently attached glycosaminoglycan side chain. Mutations in this gene are associated with multiple epiphyseal dysplasia. [provided by RefSeq, Jul 2008]