Cell atlas - ADAMTS6 - The Human Protein Atlas

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ADAMTS6

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	ADAMTS6
Gene description	ADAM metallopeptidase with thrombospondin type 1 motif, 6
Protein class	Cancer-related genes Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (U-2197, HBF TERT88, TIME)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-2197, HBF TERT88, TIME) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	ADAMTS6 (HGNC Symbol)
Synonyms	ADAM-TS6
Description	ADAM metallopeptidase with thrombospondin type 1 motif, 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q12.3
Chromosome location (bp)	65148736 - 65481920
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000049192 (version 83.38)
Entrez gene	11174
UniProt	Q9UKP5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UKP5
Antibodypedia	ADAMTS6 antibodies

PROTEIN BROWSER

ADAMTS6-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAMTS6-007 ENSP00000370443 ENST00000381055	Q9UKP5 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 6 Show all	Enzymes Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Show all	GO:0003279 [cardiac septum development] GO:0004222 [metalloendopeptidase activity] GO:0005578 [proteinaceous extracellular matrix] GO:0006508 [proteolysis] GO:0007507 [heart development] GO:0008233 [peptidase activity] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0031012 [extracellular matrix] GO:0035904 [aorta development] GO:0060976 [coronary vasculature development] Show all	1117 aa 125.3 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.