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Most cancer tissues displayed moderate cytoplasmic immunoreactivity. Additional nucleolar staining was observed in squamous cell carcinomas, melanomas, colorectal and hepatocellular carcinomas. A majority of lymphomas, gliomas, skin and renal cancers were weakly stained or negative.
GENE INFORMATION
Gene name
UTS2 (HGNC Symbol)
Synonyms
PRO1068, U-II, UCN2, UII
Description
Urotensin 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]