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Colorectal cancers and several cases of melanomas, breast, prostate and endometrial cancers showed moderate to strong cytoplasmic staining. Remaining cancer cells were in general weakly stained or negative.
Most cancer tissues showed moderate to strong cytoplasmic positivity. Lymphomas, carcinoids along with several liver, stomach, skin, testis, cervix and breast cancers were weakly stained or negative.
Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding. In human endothelial and prostate cancer cell lines this protein localizes to the plasma membrane.[provided by RefSeq, Jan 2009]
