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NEDD4L

GENERAL INFORMATION

Gene name

 NEDD4L

Gene description

 Neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 17
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA024618
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin010203040506070TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin05101520RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina050100150200Tags Per Million

GENE INFORMATION

Gene name

 NEDD4L (HGNC Symbol)

Synonyms

 KIAA0439, NEDD4-2, RSP5

Description

 Neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Chromosome

 18

Cytoband

 q21.31

Chromosome location (bp)

 58044367 - 58401540

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000049759 (version 83.38)

Entrez gene

 23327

UniProt

 Q96PU5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96PU5

Antibodypedia

 NEDD4L antibodies

PROTEIN BROWSER
«
NEDD4L-001
NEDD4L-002
NEDD4L-003
NEDD4L-004
NEDD4L-005
NEDD4L-013
NEDD4L-014
NEDD4L-016
NEDD4L-017
NEDD4L-019
NEDD4L-020
NEDD4L-022
NEDD4L-024
NEDD4L-030
NEDD4L-037
NEDD4L-042
NEDD4L-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NEDD4L-001
ENSP00000383199
ENST00000400345
Q96PU5 [Direct mapping]
E3 ubiquitin-protein ligase NEDD4-like
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003254 [regulation of membrane depolarization]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006513 [protein monoubiquitination]
GO:0006814 [sodium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007588 [excretion]
GO:0010038 [response to metal ion]
GO:0010467 [gene expression]
GO:0015459 [potassium channel regulator activity]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0017080 [sodium channel regulator activity]
GO:0019058 [viral life cycle]
GO:0019870 [potassium channel inhibitor activity]
GO:0019871 [sodium channel inhibitor activity]
GO:0030104 [water homeostasis]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042176 [regulation of protein catabolic process]
GO:0042391 [regulation of membrane potential]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044325 [ion channel binding]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045807 [positive regulation of endocytosis]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0055085 [transmembrane transport]
GO:0060306 [regulation of membrane repolarization]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0070936 [protein K48-linked ubiquitination]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:1901016 [regulation of potassium ion transmembrane transporter activity]
GO:1901017 [negative regulation of potassium ion transmembrane transporter activity]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1902306 [negative regulation of sodium ion transmembrane transport]
GO:1903861 [positive regulation of dendrite extension]
GO:2000009 [negative regulation of protein localization to cell surface]
GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]
GO:2001288 [positive regulation of caveolin-mediated endocytosis]
Show all
 975 aa
111.9 kDa 		No 0
NEDD4L-002
ENSP00000372301
ENST00000382850
Q96PU5 [Direct mapping]
E3 ubiquitin-protein ligase NEDD4-like
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003254 [regulation of membrane depolarization]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006814 [sodium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007588 [excretion]
GO:0010038 [response to metal ion]
GO:0010467 [gene expression]
GO:0015459 [potassium channel regulator activity]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0017080 [sodium channel regulator activity]
GO:0019058 [viral life cycle]
GO:0019870 [potassium channel inhibitor activity]
GO:0019871 [sodium channel inhibitor activity]
GO:0030104 [water homeostasis]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042176 [regulation of protein catabolic process]
GO:0042391 [regulation of membrane potential]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044325 [ion channel binding]
GO:0045807 [positive regulation of endocytosis]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0055085 [transmembrane transport]
GO:0060306 [regulation of membrane repolarization]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0070936 [protein K48-linked ubiquitination]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:1901016 [regulation of potassium ion transmembrane transporter activity]
GO:1901017 [negative regulation of potassium ion transmembrane transporter activity]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1902306 [negative regulation of sodium ion transmembrane transport]
GO:1903861 [positive regulation of dendrite extension]
GO:2000009 [negative regulation of protein localization to cell surface]
GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]
GO:2001288 [positive regulation of caveolin-mediated endocytosis]
Show all
 955 aa
110 kDa 		No 0
NEDD4L-003
ENSP00000350569
ENST00000357895
Q96PU5 [Direct mapping]
E3 ubiquitin-protein ligase NEDD4-like
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003254 [regulation of membrane depolarization]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006814 [sodium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007588 [excretion]
GO:0010038 [response to metal ion]
GO:0010467 [gene expression]
GO:0015459 [potassium channel regulator activity]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0017080 [sodium channel regulator activity]
GO:0019058 [viral life cycle]
GO:0019870 [potassium channel inhibitor activity]
GO:0019871 [sodium channel inhibitor activity]
GO:0030104 [water homeostasis]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042176 [regulation of protein catabolic process]
GO:0042391 [regulation of membrane potential]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044325 [ion channel binding]
GO:0045807 [positive regulation of endocytosis]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0055085 [transmembrane transport]
GO:0060306 [regulation of membrane repolarization]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0070936 [protein K48-linked ubiquitination]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:1901016 [regulation of potassium ion transmembrane transporter activity]
GO:1901017 [negative regulation of potassium ion transmembrane transporter activity]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1902306 [negative regulation of sodium ion transmembrane transport]
GO:1903861 [positive regulation of dendrite extension]
GO:2000009 [negative regulation of protein localization to cell surface]
GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]
GO:2001288 [positive regulation of caveolin-mediated endocytosis]
Show all
 967 aa
111.3 kDa 		No 0
NEDD4L-004
ENSP00000468546
ENST00000586263
Q96PU5 [Direct mapping]
E3 ubiquitin-protein ligase NEDD4-like
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003254 [regulation of membrane depolarization]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006814 [sodium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007588 [excretion]
GO:0010038 [response to metal ion]
GO:0010467 [gene expression]
GO:0015459 [potassium channel regulator activity]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0017080 [sodium channel regulator activity]
GO:0019058 [viral life cycle]
GO:0019870 [potassium channel inhibitor activity]
GO:0019871 [sodium channel inhibitor activity]
GO:0030104 [water homeostasis]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042176 [regulation of protein catabolic process]
GO:0042391 [regulation of membrane potential]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044325 [ion channel binding]
GO:0045807 [positive regulation of endocytosis]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0055085 [transmembrane transport]
GO:0060306 [regulation of membrane repolarization]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0070936 [protein K48-linked ubiquitination]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:1901016 [regulation of potassium ion transmembrane transporter activity]
GO:1901017 [negative regulation of potassium ion transmembrane transporter activity]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1902306 [negative regulation of sodium ion transmembrane transport]
GO:1903861 [positive regulation of dendrite extension]
GO:2000009 [negative regulation of protein localization to cell surface]
GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]
GO:2001288 [positive regulation of caveolin-mediated endocytosis]
Show all
 947 aa
109.4 kDa 		No 0
NEDD4L-005
ENSP00000348847
ENST00000356462
Q96PU5 [Direct mapping]
E3 ubiquitin-protein ligase NEDD4-like
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003254 [regulation of membrane depolarization]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006814 [sodium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007588 [excretion]
GO:0010038 [response to metal ion]
GO:0010467 [gene expression]
GO:0015459 [potassium channel regulator activity]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0017080 [sodium channel regulator activity]
GO:0019058 [viral life cycle]
GO:0019870 [potassium channel inhibitor activity]
GO:0019871 [sodium channel inhibitor activity]
GO:0030104 [water homeostasis]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042176 [regulation of protein catabolic process]
GO:0042391 [regulation of membrane potential]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044325 [ion channel binding]
GO:0045807 [positive regulation of endocytosis]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0055085 [transmembrane transport]
GO:0060306 [regulation of membrane repolarization]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0070936 [protein K48-linked ubiquitination]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:1901016 [regulation of potassium ion transmembrane transporter activity]
GO:1901017 [negative regulation of potassium ion transmembrane transporter activity]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1902306 [negative regulation of sodium ion transmembrane transport]
GO:1903861 [positive regulation of dendrite extension]
GO:2000009 [negative regulation of protein localization to cell surface]
GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]
GO:2001288 [positive regulation of caveolin-mediated endocytosis]
Show all
 911 aa
104.9 kDa 		No 0
NEDD4L-013
ENSP00000405440
ENST00000456173
Q96PU5 [Direct mapping]
E3 ubiquitin-protein ligase NEDD4-like
A0A024R281 [Target identity:100%; Query identity:100%]
Neural cell expressed, developmentally down-regulated 4-like, isoform CRA_b
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003254 [regulation of membrane depolarization]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006814 [sodium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007588 [excretion]
GO:0010038 [response to metal ion]
GO:0010467 [gene expression]
GO:0015459 [potassium channel regulator activity]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0017080 [sodium channel regulator activity]
GO:0019058 [viral life cycle]
GO:0019870 [potassium channel inhibitor activity]
GO:0019871 [sodium channel inhibitor activity]
GO:0030104 [water homeostasis]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042176 [regulation of protein catabolic process]
GO:0042391 [regulation of membrane potential]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044325 [ion channel binding]
GO:0045807 [positive regulation of endocytosis]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0055085 [transmembrane transport]
GO:0060306 [regulation of membrane repolarization]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0070936 [protein K48-linked ubiquitination]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:1901016 [regulation of potassium ion transmembrane transporter activity]
GO:1901017 [negative regulation of potassium ion transmembrane transporter activity]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1902306 [negative regulation of sodium ion transmembrane transport]
GO:1903861 [positive regulation of dendrite extension]
GO:2000009 [negative regulation of protein localization to cell surface]
GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]
GO:2001288 [positive regulation of caveolin-mediated endocytosis]
Show all
 834 aa
96.3 kDa 		No 0
NEDD4L-014
ENSP00000389406
ENST00000431212
Q96PU5 [Direct mapping]
E3 ubiquitin-protein ligase NEDD4-like
A0A024R2A4 [Target identity:100%; Query identity:100%]
Neural cell expressed, developmentally down-regulated 4-like, isoform CRA_h
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003254 [regulation of membrane depolarization]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006814 [sodium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007588 [excretion]
GO:0010038 [response to metal ion]
GO:0010467 [gene expression]
GO:0015459 [potassium channel regulator activity]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0017080 [sodium channel regulator activity]
GO:0019058 [viral life cycle]
GO:0019870 [potassium channel inhibitor activity]
GO:0019871 [sodium channel inhibitor activity]
GO:0030104 [water homeostasis]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042176 [regulation of protein catabolic process]
GO:0042391 [regulation of membrane potential]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044325 [ion channel binding]
GO:0045807 [positive regulation of endocytosis]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0055085 [transmembrane transport]
GO:0060306 [regulation of membrane repolarization]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0070936 [protein K48-linked ubiquitination]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:1901016 [regulation of potassium ion transmembrane transporter activity]
GO:1901017 [negative regulation of potassium ion transmembrane transporter activity]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1902306 [negative regulation of sodium ion transmembrane transport]
GO:1903861 [positive regulation of dendrite extension]
GO:2000009 [negative regulation of protein localization to cell surface]
GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]
GO:2001288 [positive regulation of caveolin-mediated endocytosis]
Show all
 854 aa
98.2 kDa 		No 0
NEDD4L-016
ENSP00000467768
ENST00000587190
K7EQC5 [Direct mapping]
E3 ubiquitin-protein ligase NEDD4-like
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
 15 aa
2 kDa 		No 0
NEDD4L-017
ENSP00000393395
ENST00000435432
Q96PU5 [Direct mapping]
E3 ubiquitin-protein ligase NEDD4-like
A0A024R281 [Target identity:100%; Query identity:100%]
Neural cell expressed, developmentally down-regulated 4-like, isoform CRA_b
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003254 [regulation of membrane depolarization]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006814 [sodium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007588 [excretion]
GO:0010038 [response to metal ion]
GO:0010467 [gene expression]
GO:0015459 [potassium channel regulator activity]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0017080 [sodium channel regulator activity]
GO:0019058 [viral life cycle]
GO:0019870 [potassium channel inhibitor activity]
GO:0019871 [sodium channel inhibitor activity]
GO:0030104 [water homeostasis]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042176 [regulation of protein catabolic process]
GO:0042391 [regulation of membrane potential]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044325 [ion channel binding]
GO:0045807 [positive regulation of endocytosis]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0055085 [transmembrane transport]
GO:0060306 [regulation of membrane repolarization]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0070936 [protein K48-linked ubiquitination]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:1901016 [regulation of potassium ion transmembrane transporter activity]
GO:1901017 [negative regulation of potassium ion transmembrane transporter activity]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1902306 [negative regulation of sodium ion transmembrane transport]
GO:1903861 [positive regulation of dendrite extension]
GO:2000009 [negative regulation of protein localization to cell surface]
GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]
GO:2001288 [positive regulation of caveolin-mediated endocytosis]
Show all
 834 aa
96.3 kDa 		No 0
NEDD4L-019
ENSP00000466789
ENST00000588494
K7EN51 [Direct mapping]
E3 ubiquitin-protein ligase NEDD4-like
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
 35 aa
4.3 kDa 		No 0
NEDD4L-020
ENSP00000466776
ENST00000592846
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
 11 aa
1.4 kDa 		No 0
NEDD4L-022
ENSP00000465669
ENST00000589054
K7EKL1 [Direct mapping]
E3 ubiquitin-protein ligase NEDD4-like
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
Show all
 106 aa
11.9 kDa 		No 0
NEDD4L-024
ENSP00000467072
ENST00000586268
K7ENS6 [Direct mapping]
E3 ubiquitin-protein ligase NEDD4-like
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 150 aa
17.6 kDa 		No 0
NEDD4L-030
ENSP00000468332
ENST00000587881
K7ERN1 [Direct mapping]
E3 ubiquitin-protein ligase NEDD4-like
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
Show all
 639 aa
74.2 kDa 		No 0
NEDD4L-037
ENSP00000256830
ENST00000256830
Q96PU5 [Direct mapping]
E3 ubiquitin-protein ligase NEDD4-like
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003254 [regulation of membrane depolarization]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006814 [sodium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007588 [excretion]
GO:0010038 [response to metal ion]
GO:0010467 [gene expression]
GO:0015459 [potassium channel regulator activity]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0017080 [sodium channel regulator activity]
GO:0019058 [viral life cycle]
GO:0019870 [potassium channel inhibitor activity]
GO:0019871 [sodium channel inhibitor activity]
GO:0030104 [water homeostasis]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042176 [regulation of protein catabolic process]
GO:0042391 [regulation of membrane potential]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044325 [ion channel binding]
GO:0045807 [positive regulation of endocytosis]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0055085 [transmembrane transport]
GO:0060306 [regulation of membrane repolarization]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0070936 [protein K48-linked ubiquitination]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:1901016 [regulation of potassium ion transmembrane transporter activity]
GO:1901017 [negative regulation of potassium ion transmembrane transporter activity]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1902306 [negative regulation of sodium ion transmembrane transport]
GO:1903861 [positive regulation of dendrite extension]
GO:2000009 [negative regulation of protein localization to cell surface]
GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]
GO:2001288 [positive regulation of caveolin-mediated endocytosis]
Show all
 871 aa
100.8 kDa 		No 0
NEDD4L-042
ENSP00000479462
ENST00000617539
A0A087WVI6 [Direct mapping]
E3 ubiquitin-protein ligase NEDD4-like
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
 20 aa
2 kDa 		No 0
NEDD4L-201
ENSP00000411947
ENST00000456986
Q96PU5 [Direct mapping]
E3 ubiquitin-protein ligase NEDD4-like
A0A024R2A4 [Target identity:100%; Query identity:100%]
Neural cell expressed, developmentally down-regulated 4-like, isoform CRA_h
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003254 [regulation of membrane depolarization]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006814 [sodium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007588 [excretion]
GO:0010038 [response to metal ion]
GO:0010467 [gene expression]
GO:0015459 [potassium channel regulator activity]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0017080 [sodium channel regulator activity]
GO:0019058 [viral life cycle]
GO:0019870 [potassium channel inhibitor activity]
GO:0019871 [sodium channel inhibitor activity]
GO:0030104 [water homeostasis]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042176 [regulation of protein catabolic process]
GO:0042391 [regulation of membrane potential]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044325 [ion channel binding]
GO:0045807 [positive regulation of endocytosis]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0055085 [transmembrane transport]
GO:0060306 [regulation of membrane repolarization]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0070936 [protein K48-linked ubiquitination]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:1901016 [regulation of potassium ion transmembrane transporter activity]
GO:1901017 [negative regulation of potassium ion transmembrane transporter activity]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1902306 [negative regulation of sodium ion transmembrane transport]
GO:1903861 [positive regulation of dendrite extension]
GO:2000009 [negative regulation of protein localization to cell surface]
GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]
GO:2001288 [positive regulation of caveolin-mediated endocytosis]
Show all
 854 aa
98.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.