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FOXP3

GENERAL INFORMATION

Gene name

 FOXP3

Gene description

 Forkhead box P3

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (appendix)
GTEx:Mixed
FANTOM5:Group enriched (appendix, tonsil, lymph node)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in a subset of immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB026301
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (appendix, tonsil, lymph node)

GENE INFORMATION

Gene name

 FOXP3 (HGNC Symbol)

Synonyms

 AIID, DIETER, IPEX, JM2, PIDX, SCURFIN, XPID

Description

 Forkhead box P3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 p11.23

Chromosome location (bp)

 49250436 - 49264826

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000049768 (version 83.38)

Entrez gene

 50943

UniProt

 Q9BZS1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BZS1

Antibodypedia

 FOXP3 antibodies

PROTEIN BROWSER
FOXP3-001
FOXP3-002
FOXP3-003
FOXP3-004
FOXP3-201
FOXP3-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FOXP3-001
ENSP00000365380
ENST00000376207
Q9BZS1 [Direct mapping]
Forkhead box protein P3 Forkhead box protein P3, C-terminally processed Forkhead box protein P3 41 kDa form
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0001782 [B cell homeostasis]
GO:0001816 [cytokine production]
GO:0002262 [myeloid cell homeostasis]
GO:0002361 [CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation]
GO:0002362 [CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment]
GO:0002456 [T cell mediated immunity]
GO:0002507 [tolerance induction]
GO:0002513 [tolerance induction to self antigen]
GO:0002637 [regulation of immunoglobulin production]
GO:0002666 [positive regulation of T cell tolerance induction]
GO:0002667 [regulation of T cell anergy]
GO:0002669 [positive regulation of T cell anergy]
GO:0002677 [negative regulation of chronic inflammatory response]
GO:0002725 [negative regulation of T cell cytokine production]
GO:0002851 [positive regulation of peripheral T cell tolerance induction]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008285 [negative regulation of cell proliferation]
GO:0009615 [response to virus]
GO:0009653 [anatomical structure morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0031064 [negative regulation of histone deacetylation]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032693 [negative regulation of interleukin-10 production]
GO:0032700 [negative regulation of interleukin-17 production]
GO:0032703 [negative regulation of interleukin-2 production]
GO:0032713 [negative regulation of interleukin-4 production]
GO:0032714 [negative regulation of interleukin-5 production]
GO:0032715 [negative regulation of interleukin-6 production]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0032792 [negative regulation of CREB transcription factor activity]
GO:0032831 [positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation]
GO:0032914 [positive regulation of transforming growth factor beta1 production]
GO:0033092 [positive regulation of immature T cell proliferation in thymus]
GO:0035035 [histone acetyltransferase binding]
GO:0035066 [positive regulation of histone acetylation]
GO:0035067 [negative regulation of histone acetylation]
GO:0042036 [negative regulation of cytokine biosynthetic process]
GO:0042110 [T cell activation]
GO:0042130 [negative regulation of T cell proliferation]
GO:0042803 [protein homodimerization activity]
GO:0042826 [histone deacetylase binding]
GO:0043029 [T cell homeostasis]
GO:0043234 [protein complex]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045066 [regulatory T cell differentiation]
GO:0045077 [negative regulation of interferon-gamma biosynthetic process]
GO:0045085 [negative regulation of interleukin-2 biosynthetic process]
GO:0045591 [positive regulation of regulatory T cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046007 [negative regulation of activated T cell proliferation]
GO:0046872 [metal ion binding]
GO:0048294 [negative regulation of isotype switching to IgE isotypes]
GO:0048302 [regulation of isotype switching to IgG isotypes]
GO:0050672 [negative regulation of lymphocyte proliferation]
GO:0050710 [negative regulation of cytokine secretion]
GO:0050728 [negative regulation of inflammatory response]
GO:0050777 [negative regulation of immune response]
GO:0050852 [T cell receptor signaling pathway]
GO:0051059 [NF-kappaB binding]
GO:0051525 [NFAT protein binding]
GO:2000320 [negative regulation of T-helper 17 cell differentiation]
Show all
 431 aa
47.2 kDa 		No 0
FOXP3-002
ENSP00000365369
ENST00000376197
A0A0C4DFW6 [Direct mapping]
Forkhead box P3, isoform CRA_b; Forkhead box protein P3
Show all
Predicted intracellular proteins
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0009653 [anatomical structure morphogenesis]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0046872 [metal ion binding]
Show all
 441 aa
48.4 kDa 		No 0
FOXP3-003
ENSP00000428952
ENST00000518685
Q9BZS1 [Direct mapping]
Forkhead box protein P3 Forkhead box protein P3, C-terminally processed Forkhead box protein P3 41 kDa form
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0002362 [CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment]
GO:0002667 [regulation of T cell anergy]
GO:0002725 [negative regulation of T cell cytokine production]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008285 [negative regulation of cell proliferation]
GO:0009615 [response to virus]
GO:0009653 [anatomical structure morphogenesis]
GO:0030154 [cell differentiation]
GO:0031064 [negative regulation of histone deacetylation]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032693 [negative regulation of interleukin-10 production]
GO:0032700 [negative regulation of interleukin-17 production]
GO:0032703 [negative regulation of interleukin-2 production]
GO:0032713 [negative regulation of interleukin-4 production]
GO:0032792 [negative regulation of CREB transcription factor activity]
GO:0032831 [positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation]
GO:0035035 [histone acetyltransferase binding]
GO:0035066 [positive regulation of histone acetylation]
GO:0042036 [negative regulation of cytokine biosynthetic process]
GO:0042110 [T cell activation]
GO:0042130 [negative regulation of T cell proliferation]
GO:0042803 [protein homodimerization activity]
GO:0042826 [histone deacetylase binding]
GO:0043029 [T cell homeostasis]
GO:0043234 [protein complex]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045085 [negative regulation of interleukin-2 biosynthetic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046007 [negative regulation of activated T cell proliferation]
GO:0046872 [metal ion binding]
GO:0050710 [negative regulation of cytokine secretion]
GO:0050777 [negative regulation of immune response]
GO:0051059 [NF-kappaB binding]
GO:0051525 [NFAT protein binding]
GO:2000320 [negative regulation of T-helper 17 cell differentiation]
Show all
 396 aa
43.4 kDa 		No 0
FOXP3-004
ENSP00000451208
ENST00000557224
Q9BZS1 [Direct mapping]
Forkhead box protein P3 Forkhead box protein P3, C-terminally processed Forkhead box protein P3 41 kDa form
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0002362 [CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment]
GO:0002667 [regulation of T cell anergy]
GO:0002725 [negative regulation of T cell cytokine production]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008285 [negative regulation of cell proliferation]
GO:0009615 [response to virus]
GO:0009653 [anatomical structure morphogenesis]
GO:0030154 [cell differentiation]
GO:0031064 [negative regulation of histone deacetylation]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032693 [negative regulation of interleukin-10 production]
GO:0032700 [negative regulation of interleukin-17 production]
GO:0032703 [negative regulation of interleukin-2 production]
GO:0032713 [negative regulation of interleukin-4 production]
GO:0032792 [negative regulation of CREB transcription factor activity]
GO:0032831 [positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation]
GO:0035035 [histone acetyltransferase binding]
GO:0035066 [positive regulation of histone acetylation]
GO:0042036 [negative regulation of cytokine biosynthetic process]
GO:0042110 [T cell activation]
GO:0042130 [negative regulation of T cell proliferation]
GO:0042803 [protein homodimerization activity]
GO:0042826 [histone deacetylase binding]
GO:0043029 [T cell homeostasis]
GO:0043234 [protein complex]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045085 [negative regulation of interleukin-2 biosynthetic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046007 [negative regulation of activated T cell proliferation]
GO:0046872 [metal ion binding]
GO:0050710 [negative regulation of cytokine secretion]
GO:0050777 [negative regulation of immune response]
GO:0051059 [NF-kappaB binding]
GO:0051525 [NFAT protein binding]
GO:2000320 [negative regulation of T-helper 17 cell differentiation]
Show all
 456 aa
49.8 kDa 		No 0
FOXP3-201
ENSP00000365372
ENST00000376199
Q9BZS1 [Direct mapping]
Forkhead box protein P3 Forkhead box protein P3, C-terminally processed Forkhead box protein P3 41 kDa form
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0002362 [CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment]
GO:0002667 [regulation of T cell anergy]
GO:0002725 [negative regulation of T cell cytokine production]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008285 [negative regulation of cell proliferation]
GO:0009615 [response to virus]
GO:0009653 [anatomical structure morphogenesis]
GO:0030154 [cell differentiation]
GO:0031064 [negative regulation of histone deacetylation]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032693 [negative regulation of interleukin-10 production]
GO:0032700 [negative regulation of interleukin-17 production]
GO:0032703 [negative regulation of interleukin-2 production]
GO:0032713 [negative regulation of interleukin-4 production]
GO:0032792 [negative regulation of CREB transcription factor activity]
GO:0032831 [positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation]
GO:0035035 [histone acetyltransferase binding]
GO:0035066 [positive regulation of histone acetylation]
GO:0042036 [negative regulation of cytokine biosynthetic process]
GO:0042110 [T cell activation]
GO:0042130 [negative regulation of T cell proliferation]
GO:0042803 [protein homodimerization activity]
GO:0042826 [histone deacetylase binding]
GO:0043029 [T cell homeostasis]
GO:0043234 [protein complex]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045085 [negative regulation of interleukin-2 biosynthetic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046007 [negative regulation of activated T cell proliferation]
GO:0046872 [metal ion binding]
GO:0050710 [negative regulation of cytokine secretion]
GO:0050777 [negative regulation of immune response]
GO:0051059 [NF-kappaB binding]
GO:0051525 [NFAT protein binding]
GO:2000320 [negative regulation of T-helper 17 cell differentiation]
Show all
 396 aa
43.4 kDa 		No 0
FOXP3-202
ENSP00000396415
ENST00000455775
B7ZLG1 [Direct mapping]
FOXP3 protein; Forkhead box protein P3
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0002361 [CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0009653 [anatomical structure morphogenesis]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0046872 [metal ion binding]
Show all
 454 aa
49.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.