Cell atlas - KIAA2022 - The Human Protein Atlas

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KIAA2022

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Midbody
	Nucleoplasm

Human cell
	Microtubules
	Nucleoplasm

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GENERAL INFORMATION
Gene name	KIAA2022
Gene description	KIAA2022
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the midbody & nucleoplasm.
RNA cell category	Group enriched (SiHa, Karpas-707)
Protein evidence	Evidence at transcript level
Main location	Localized to the Nucleoplasm (uncertain), Midbody (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA000407
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (SiHa, Karpas-707) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the midbody & nucleoplasm.

Main location

Nucleoplasm (uncertain), Midbody (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA000407	SiHa	Nucleoplasm
	HPA000407	SiHa	Midbody	Intensity	Intensity
	HPA000407	U-2 OS	Nucleoplasm
	HPA000407	U-251 MG	Nucleoplasm

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition

GENE INFORMATION
Gene name	KIAA2022 (HGNC Symbol)
Synonyms	MRX98, XPN
Description	KIAA2022 (HGNC Symbol)
Entrez gene summary	An inversion on the X chromosome which disrupts this gene and a G-protein coupled purinergic receptor gene located in the pseudoautosomal region of the X chromosome has been linked to X linked mental retardation.[provided by RefSeq, Mar 2009]
Chromosome	X
Cytoband	q13.3
Chromosome location (bp)	74732849 - 74925485
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000050030 (version 83.38)
Entrez gene	340533
UniProt	Q5QGS0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5QGS0
Antibodypedia	KIAA2022 antibodies

PROTEIN BROWSER

KIAA2022-001	KIAA2022-002	KIAA2022-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KIAA2022-001 ENSP00000055682 ENST00000055682	Q5QGS0 [Direct mapping] Protein KIAA2022 Show all	Predicted intracellular proteins Disease related genes Show all	GO:0003887 [DNA-directed DNA polymerase activity] GO:0006261 [DNA-dependent DNA replication] GO:0007399 [nervous system development] GO:0016035 [zeta DNA polymerase complex] GO:0042276 [error-prone translesion synthesis] Show all	1516 aa 167.6 kDa	No	0
KIAA2022-002 ENSP00000407055 ENST00000424929	H7C2N8 [Direct mapping] Protein KIAA2022 Show all	Predicted intracellular proteins Show all	GO:0003887 [DNA-directed DNA polymerase activity] GO:0006261 [DNA-dependent DNA replication] GO:0016035 [zeta DNA polymerase complex] GO:0042276 [error-prone translesion synthesis] Show all	118 aa 13.5 kDa	No	0
KIAA2022-201 ENSP00000480284 ENST00000616200	Q5QGS0 [Direct mapping] Protein KIAA2022 Show all	Predicted intracellular proteins Disease related genes Show all	GO:0003887 [DNA-directed DNA polymerase activity] GO:0006261 [DNA-dependent DNA replication] GO:0007399 [nervous system development] GO:0016035 [zeta DNA polymerase complex] GO:0042276 [error-prone translesion synthesis] Show all	1516 aa 167.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.