Cell atlas - LETMD1 - The Human Protein Atlas

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LETMD1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Nucleoplasm

Human cell
	Mitochondria
	Nucleoplasm

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GENERAL INFORMATION
Gene name	LETMD1
Gene description	LETM1 domain containing 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	16
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria. In addition localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)
Additional location	In addition localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA074361
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria. In addition localized to the nucleoplasm.

Main location

Mitochondria (supported)

Additional location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA074361	SK-MEL-30	Nucleoplasm
	HPA074361	SK-MEL-30	Mitochondria
	HPA074361	U-2 OS	Mitochondria

GENE INFORMATION
Gene name	LETMD1 (HGNC Symbol)
Synonyms	HCCR1
Description	LETM1 domain containing 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a mitochondrial outer membrane protein. It has a potential role in tumorigenesis, which may result from negative regulation of the p53 tumor suppressor gene. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Aug 2011]
Chromosome	12
Cytoband	q13.12
Chromosome location (bp)	51047962 - 51060424
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000050426 (version 83.38)
Entrez gene	25875
UniProt	Q6P1Q0 (UniProt - Evidence at protein level)
neXtProt	NX_Q6P1Q0
Antibodypedia	LETMD1 antibodies

PROTEIN BROWSER

LETMD1-001	LETMD1-003	LETMD1-006	LETMD1-008	LETMD1-012	LETMD1-015	LETMD1-019	LETMD1-024	LETMD1-025	LETMD1-026	LETMD1-027	LETMD1-028	LETMD1-034	LETMD1-036	LETMD1-037	LETMD1-038

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LETMD1-001 ENSP00000262055 ENST00000262055	Q6P1Q0 [Direct mapping] LETM1 domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005741 [mitochondrial outer membrane] GO:0016021 [integral component of membrane] Show all	360 aa 41.8 kDa	No	2
LETMD1-003 ENSP00000450163 ENST00000550929	Q6P1Q0 [Direct mapping] LETM1 domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005741 [mitochondrial outer membrane] GO:0016021 [integral component of membrane] Show all	304 aa 35.7 kDa	No	2
LETMD1-006 ENSP00000389903 ENST00000418425	Q6P1Q0 [Direct mapping] LETM1 domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0016021 [integral component of membrane] Show all	373 aa 43.3 kDa	No	1
LETMD1-008 ENSP00000447419 ENST00000547008	F8W1Z2 [Direct mapping] LETM1 domain-containing protein 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		236 aa 27.2 kDa	No	0
LETMD1-012 ENSP00000450333 ENST00000552739	F8VP71 [Direct mapping] LETM1 domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		243 aa 27.7 kDa	No	0
LETMD1-015 ENSP00000446862 ENST00000551477	F8VZA2 [Direct mapping] LETM1 domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	291 aa 34.1 kDa	No	1
LETMD1-019 ENSP00000449896 ENST00000549340	F8VVQ3 [Direct mapping] LETM1 domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	261 aa 29.9 kDa	No	1
LETMD1-024 ENSP00000450275 ENST00000548209	F8VPY5 [Direct mapping] LETM1 domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		179 aa 20.5 kDa	No	0
LETMD1-025 ENSP00000447166 ENST00000548251	F8W0R0 [Direct mapping] LETM1 domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		184 aa 20.8 kDa	No	0
LETMD1-026 ENSP00000448222 ENST00000550814	F8VS60 [Direct mapping] LETM1 domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		158 aa 18.2 kDa	No	0
LETMD1-027 ENSP00000450391 ENST00000547660	F8VR33 [Direct mapping] LETM1 domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		109 aa 12.2 kDa	No	0
LETMD1-028 ENSP00000450082 ENST00000548401	F8VQE7 [Direct mapping] LETM1 domain-containing protein 1 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		135 aa 15.8 kDa	No	0
LETMD1-034 ENSP00000448110 ENST00000550442	F8VTR1 [Direct mapping] LETM1 domain-containing protein 1 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		144 aa 16.8 kDa	No	0
LETMD1-036 ENSP00000446551 ENST00000547256	H0YH93 [Direct mapping] LETM1 domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		110 aa 12.2 kDa	No	0
LETMD1-037 ENSP00000450251 ENST00000551931	H0YIV5 [Direct mapping] LETM1 domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		144 aa 16.3 kDa	No	0
LETMD1-038 ENSP00000446967 ENST00000553043	H0YHF4 [Direct mapping] LETM1 domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		98 aa 10.6 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.