Tissue expression of SLC4A8 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SLC4A8
Gene description	Solute carrier family 4, sodium bicarbonate cotransporter, member 8
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (testis, cerebral cortex)
GTEx:	Tissue enhanced (pituitary gland, testis)
FANTOM5:	Tissue enhanced (pituitary gland, testis)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis, cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (pituitary gland, testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (pituitary gland, testis)

GENE INFORMATION
Gene name	SLC4A8 (HGNC Symbol)
Synonyms	NBC3
Description	Solute carrier family 4, sodium bicarbonate cotransporter, member 8 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a membrane protein that functions to transport sodium and bicarbonate ions across the cell membrane. The encoded protein is important for pH regulation in neurons. The activity of this protein can be inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Chromosome	12
Cytoband	q13.13
Chromosome location (bp)	51391317 - 51515763
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000050438 (version 83.38)
Entrez gene	9498
UniProt	Q2Y0W8 (UniProt - Evidence at protein level)
neXtProt	NX_Q2Y0W8
Antibodypedia	SLC4A8 antibodies

PROTEIN BROWSER

SLC4A8-001	SLC4A8-003	SLC4A8-016	SLC4A8-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC4A8-001 ENSP00000405812 ENST00000453097	Q2Y0W8 [Direct mapping] Electroneutral sodium bicarbonate exchanger 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005452 [inorganic anion exchanger activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006820 [anion transport] GO:0008509 [anion transmembrane transporter activity] GO:0008510 [sodium:bicarbonate symporter activity] GO:0015701 [bicarbonate transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0032809 [neuronal cell body membrane] GO:0035725 [sodium ion transmembrane transport] GO:0043005 [neuron projection] GO:0051453 [regulation of intracellular pH] GO:0055085 [transmembrane transport] GO:0098656 [anion transmembrane transport] Show all	1093 aa 122.9 kDa	No	>9
SLC4A8-003 ENSP00000442561 ENST00000514353	Q2Y0W8 [Direct mapping] Electroneutral sodium bicarbonate exchanger 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005452 [inorganic anion exchanger activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006820 [anion transport] GO:0008509 [anion transmembrane transporter activity] GO:0008510 [sodium:bicarbonate symporter activity] GO:0015701 [bicarbonate transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] GO:0051453 [regulation of intracellular pH] GO:0055085 [transmembrane transport] GO:0098656 [anion transmembrane transport] Show all	747 aa 84 kDa	No	6
SLC4A8-016 ENSP00000441520 ENST00000535225	Q2Y0W8 [Direct mapping] Electroneutral sodium bicarbonate exchanger 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005452 [inorganic anion exchanger activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006820 [anion transport] GO:0008509 [anion transmembrane transporter activity] GO:0008510 [sodium:bicarbonate symporter activity] GO:0015701 [bicarbonate transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] GO:0051453 [regulation of intracellular pH] GO:0055085 [transmembrane transport] GO:0098656 [anion transmembrane transport] Show all	638 aa 71.3 kDa	No	4
SLC4A8-201 ENSP00000351483 ENST00000358657	Q2Y0W8 [Direct mapping] Electroneutral sodium bicarbonate exchanger 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005452 [inorganic anion exchanger activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006820 [anion transport] GO:0008509 [anion transmembrane transporter activity] GO:0008510 [sodium:bicarbonate symporter activity] GO:0015701 [bicarbonate transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] GO:0051453 [regulation of intracellular pH] GO:0055085 [transmembrane transport] GO:0098656 [anion transmembrane transport] Show all	1040 aa 117.1 kDa	No	>9