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Gene name

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PTGER3
  • TISSUE

  • CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

Prostaglandin E receptor 3 (subtype EP3)

Protein class

FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins

Protein evidence

Evidence at transcript level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Cervical cancer

STAINING SUMMARY

HPA010689

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Majority of breast cancers displayed moderate to strong cytoplasmic and membranous staining. Urothelial, cervical, endometrial and testicular cancers showed moderate to strong nuclear and/ or cytoplasmic membranous positivity. Few cases of ovarian and stomach cancers displayed moderate to strong nuclear staining. Remaining cancer tissues were weakly stained or negative.

GENE INFORMATION

Gene name

PTGER3 (HGNC Symbol)

Synonyms

EP3

Description

Prostaglandin E receptor 3 (subtype EP3) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

Chromosome

1

Cytoband

p31.1

Chromosome location (bp)

70852353 - 71047808

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000050628 (version 83.38)

Entrez gene

5733

UniProt

P43115 (UniProt - Evidence at transcript level)

neXtProt

NX_P43115

Antibodypedia

PTGER3 antibodies

PROTEIN BROWSER

PTGER3-004
PTGER3-005
PTGER3-006
PTGER3-007
PTGER3-008
PTGER3-009
PTGER3-201
PTGER3-202
PTGER3-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTGER3-004
ENSP00000349003
ENST00000356595
P43115 [Direct mapping]
Prostaglandin E2 receptor EP3 subtype
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001660 [fever generation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002029 [desensitization of G-protein coupled receptor protein signaling pathway]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004930 [G-protein coupled receptor activity]
GO:0004957 [prostaglandin E receptor activity]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007565 [female pregnancy]
GO:0008219 [cell death]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010700 [negative regulation of norepinephrine secretion]
GO:0010840 [regulation of circadian sleep/wake cycle, wakefulness]
GO:0014061 [regulation of norepinephrine secretion]
GO:0014827 [intestine smooth muscle contraction]
GO:0014832 [urinary bladder smooth muscle contraction]
GO:0015701 [bicarbonate transport]
GO:0016021 [integral component of membrane]
GO:0030522 [intracellular receptor signaling pathway]
GO:0030818 [negative regulation of cAMP biosynthetic process]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0031526 [brush border membrane]
GO:0031622 [positive regulation of fever generation]
GO:0031623 [receptor internalization]
GO:0031965 [nuclear membrane]
GO:0032355 [response to estradiol]
GO:0032496 [response to lipopolysaccharide]
GO:0032570 [response to progesterone]
GO:0035810 [positive regulation of urine volume]
GO:0042493 [response to drug]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0045907 [positive regulation of vasoconstriction]
GO:0046010 [positive regulation of circadian sleep/wake cycle, non-REM sleep]
GO:0046676 [negative regulation of insulin secretion]
GO:0060137 [maternal process involved in parturition]
GO:0060455 [negative regulation of gastric acid secretion]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071347 [cellular response to interleukin-1]
GO:0090331 [negative regulation of platelet aggregation]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1902074 [response to salt]
GO:1903170 [negative regulation of calcium ion transmembrane transport]
GO:1903524 [positive regulation of blood circulation]
GO:1903640 [negative regulation of gastrin-induced gastric acid secretion]
GO:1904320 [positive regulation of smooth muscle contraction involved in micturition]
GO:1904322 [cellular response to forskolin]
GO:1904325 [positive regulation of inhibitory G-protein coupled receptor phosphorylation]
GO:1904326 [negative regulation of circadian sleep/wake cycle, wakefulness]
GO:1904330 [positive regulation of myofibroblast contraction]
GO:1904343 [positive regulation of colon smooth muscle contraction]
GO:1904346 [positive regulation of gastric mucosal blood circulation]
GO:1990767 [prostaglandin receptor internalization]
GO:1990769 [proximal neuron projection]
GO:2000391 [positive regulation of neutrophil extravasation]
GO:2000978 [negative regulation of forebrain neuron differentiation]
Show all
418 aa
46.7 kDa
No 7
PTGER3-005
ENSP00000302313
ENST00000306666
P43115 [Direct mapping]
Prostaglandin E2 receptor EP3 subtype
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004930 [G-protein coupled receptor activity]
GO:0004957 [prostaglandin E receptor activity]
GO:0005635 [nuclear envelope]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008219 [cell death]
GO:0016021 [integral component of membrane]
GO:0030522 [intracellular receptor signaling pathway]
GO:0031622 [positive regulation of fever generation]
Show all
390 aa
43.3 kDa
No 7
PTGER3-006
ENSP00000359969
ENST00000370931
P43115 [Direct mapping]
Prostaglandin E2 receptor EP3 subtype
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004930 [G-protein coupled receptor activity]
GO:0004957 [prostaglandin E receptor activity]
GO:0005635 [nuclear envelope]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008219 [cell death]
GO:0016021 [integral component of membrane]
GO:0030522 [intracellular receptor signaling pathway]
GO:0031622 [positive regulation of fever generation]
Show all
390 aa
43.3 kDa
No 7
PTGER3-007
ENSP00000418073
ENST00000460330
P43115 [Direct mapping]
Prostaglandin E2 receptor EP3 subtype
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004930 [G-protein coupled receptor activity]
GO:0004957 [prostaglandin E receptor activity]
GO:0005635 [nuclear envelope]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008219 [cell death]
GO:0016021 [integral component of membrane]
GO:0030522 [intracellular receptor signaling pathway]
GO:0031622 [positive regulation of fever generation]
Show all
374 aa
41.8 kDa
No 7
PTGER3-008
ENSP00000359962
ENST00000370924
P43115 [Direct mapping]
Prostaglandin E2 receptor EP3 subtype
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004930 [G-protein coupled receptor activity]
GO:0004957 [prostaglandin E receptor activity]
GO:0005635 [nuclear envelope]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008219 [cell death]
GO:0016021 [integral component of membrane]
GO:0030522 [intracellular receptor signaling pathway]
GO:0031622 [positive regulation of fever generation]
Show all
388 aa
42.7 kDa
No 7
PTGER3-009
ENSP00000486617
ENST00000628037
P43115 [Direct mapping]
Prostaglandin E2 receptor EP3 subtype
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004930 [G-protein coupled receptor activity]
GO:0004957 [prostaglandin E receptor activity]
GO:0005635 [nuclear envelope]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008219 [cell death]
GO:0016021 [integral component of membrane]
GO:0030522 [intracellular receptor signaling pathway]
GO:0031622 [positive regulation of fever generation]
Show all
365 aa
40.5 kDa
No 7
PTGER3-201
ENSP00000280208
ENST00000351052
P43115 [Direct mapping]
Prostaglandin E2 receptor EP3 subtype
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004930 [G-protein coupled receptor activity]
GO:0004957 [prostaglandin E receptor activity]
GO:0005635 [nuclear envelope]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008219 [cell death]
GO:0016021 [integral component of membrane]
GO:0030522 [intracellular receptor signaling pathway]
GO:0031622 [positive regulation of fever generation]
Show all
390 aa
43.3 kDa
No 7
PTGER3-202
ENSP00000346624
ENST00000354608
F8WAJ7 [Direct mapping]
Prostaglandin E2 receptor EP3 subtype
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004957 [prostaglandin E receptor activity]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
Show all
412 aa
45.7 kDa
No 7
PTGER3-203
ENSP00000359970
ENST00000370932
A0A0A0MRP3 [Direct mapping]
Prostaglandin E2 receptor EP3 subtype
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004957 [prostaglandin E receptor activity]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
Show all
388 aa
42.9 kDa
No 7

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