Expression of HERPUD1 in cancer - Summary

CANCER ATLAS

Gene description

Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1

Protein class

Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Thyroid cancer

STAINING SUMMARY

HPA040754	HPA041219	CAB037041	CAB037104

GENE INFORMATION
Gene name	HERPUD1 (HGNC Symbol)
Synonyms	HERP, KIAA0025, Mif1, SUP
Description	Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 (HGNC Symbol)
Entrez gene summary	The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq, Jan 2013]
Chromosome	16
Cytoband	q13
Chromosome location (bp)	56932048 - 56944863
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000051108 (version 83.38)
Entrez gene	9709
UniProt	Q15011 (UniProt - Evidence at protein level)
neXtProt	NX_Q15011
Antibodypedia	HERPUD1 antibodies

PROTEIN BROWSER

HERPUD1-001	HERPUD1-002	HERPUD1-003	HERPUD1-004	HERPUD1-012	HERPUD1-013	HERPUD1-014	HERPUD1-016	HERPUD1-019

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HERPUD1-001 ENSP00000409555 ENST00000439977	Q15011 [Direct mapping] Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006874 [cellular calcium ion homeostasis] GO:0006986 [response to unfolded protein] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0030970 [retrograde protein transport, ER to cytosol] GO:0031396 [regulation of protein ubiquitination] GO:0032092 [positive regulation of protein binding] GO:0032469 [endoplasmic reticulum calcium ion homeostasis] GO:0034704 [calcium channel complex] GO:0034976 [response to endoplasmic reticulum stress] GO:0036499 [PERK-mediated unfolded protein response] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044267 [cellular protein metabolic process] GO:0044325 [ion channel binding] GO:1902235 [regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903069 [regulation of ER-associated ubiquitin-dependent protein catabolic process] GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process] GO:1990037 [Lewy body core] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] Show all	391 aa 43.7 kDa	No	2
HERPUD1-002 ENSP00000300302 ENST00000300302	Q15011 [Direct mapping] Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006986 [response to unfolded protein] GO:0016020 [membrane] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0030970 [retrograde protein transport, ER to cytosol] GO:0032469 [endoplasmic reticulum calcium ion homeostasis] GO:0034704 [calcium channel complex] GO:0034976 [response to endoplasmic reticulum stress] GO:0036499 [PERK-mediated unfolded protein response] GO:0044267 [cellular protein metabolic process] GO:0044325 [ion channel binding] GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process] GO:1990037 [Lewy body core] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] Show all	390 aa 43.6 kDa	No	2
HERPUD1-003 ENSP00000369118 ENST00000379792	Q15011 [Direct mapping] Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006986 [response to unfolded protein] GO:0016020 [membrane] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0030970 [retrograde protein transport, ER to cytosol] GO:0032469 [endoplasmic reticulum calcium ion homeostasis] GO:0034704 [calcium channel complex] GO:0034976 [response to endoplasmic reticulum stress] GO:0036499 [PERK-mediated unfolded protein response] GO:0044267 [cellular protein metabolic process] GO:0044325 [ion channel binding] GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process] GO:1990037 [Lewy body core] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] Show all	366 aa 40.9 kDa	No	2
HERPUD1-004 ENSP00000340931 ENST00000344114	Q15011 [Direct mapping] Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006986 [response to unfolded protein] GO:0016020 [membrane] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0030970 [retrograde protein transport, ER to cytosol] GO:0032469 [endoplasmic reticulum calcium ion homeostasis] GO:0034704 [calcium channel complex] GO:0034976 [response to endoplasmic reticulum stress] GO:0036499 [PERK-mediated unfolded protein response] GO:0044267 [cellular protein metabolic process] GO:0044325 [ion channel binding] GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process] GO:1990037 [Lewy body core] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] Show all	232 aa 26.2 kDa	No	0
HERPUD1-012 ENSP00000457321 ENST00000569429	H3BTT7 [Direct mapping] Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	150 aa 16.6 kDa	No	0
HERPUD1-013 ENSP00000455094 ENST00000563343	H3BP08 [Direct mapping] Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	160 aa 18 kDa	No	0
HERPUD1-014 ENSP00000457955 ENST00000568651	H3BV54 [Direct mapping] Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	150 aa 17.1 kDa	No	1
HERPUD1-016 ENSP00000455841 ENST00000563911	H3BQM2 [Direct mapping] Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	226 aa 24.5 kDa	No	1
HERPUD1-019 ENSP00000457095 ENST00000568358	H3BTA8 [Direct mapping] Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		109 aa 12.3 kDa	No	0