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RAD51

CANCER ATLAS

Gene description

 RAD51 recombinase

Protein class

 Cancer-related genes, Disease related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039310

GENE INFORMATION

Gene name

 RAD51 (HGNC Symbol)

Synonyms

 BRCC5, FANCR, HsRad51, HsT16930, RAD51A, RECA

Description

 RAD51 recombinase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

Chromosome

 15

Cytoband

 q15.1

Chromosome location (bp)

 40694774 - 40732339

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000051180 (version 83.38)

Entrez gene

 5888

UniProt

 Q06609 (UniProt - Evidence at protein level)

neXtProt

 NX_Q06609

Antibodypedia

 RAD51 antibodies

PROTEIN BROWSER
RAD51-001
RAD51-002
RAD51-003
RAD51-006
RAD51-007
RAD51-008
RAD51-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAD51-001
ENSP00000267868
ENST00000267868
Q06609 [Direct mapping]
DNA repair protein RAD51 homolog 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000150 [recombinase activity]
GO:0000166 [nucleotide binding]
GO:0000228 [nuclear chromosome]
GO:0000400 [four-way junction DNA binding]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000785 [chromatin]
GO:0000793 [condensed chromosome]
GO:0000794 [condensed nuclear chromosome]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0004520 [endodeoxyribonuclease activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005815 [microtubule organizing center]
GO:0006259 [DNA metabolic process]
GO:0006268 [DNA unwinding involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006310 [DNA recombination]
GO:0006312 [mitotic recombination]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007126 [meiotic nuclear division]
GO:0007131 [reciprocal meiotic recombination]
GO:0008022 [protein C-terminus binding]
GO:0008094 [DNA-dependent ATPase activity]
GO:0010569 [regulation of double-strand break repair via homologous recombination]
GO:0016605 [PML body]
GO:0031297 [replication fork processing]
GO:0035861 [site of double-strand break]
GO:0042148 [strand invasion]
GO:0042802 [identical protein binding]
GO:0043142 [single-stranded DNA-dependent ATPase activity]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051106 [positive regulation of DNA ligation]
GO:0051260 [protein homooligomerization]
GO:0070182 [DNA polymerase binding]
GO:0070192 [chromosome organization involved in meiosis]
GO:0071479 [cellular response to ionizing radiation]
GO:0072757 [cellular response to camptothecin]
GO:1990426 [homologous recombination-dependent replication fork processing]
Show all
 339 aa
37 kDa 		No 0
RAD51-002
ENSP00000406602
ENST00000423169
Q06609 [Direct mapping]
DNA repair protein RAD51 homolog 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000150 [recombinase activity]
GO:0000166 [nucleotide binding]
GO:0000228 [nuclear chromosome]
GO:0000400 [four-way junction DNA binding]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000785 [chromatin]
GO:0000793 [condensed chromosome]
GO:0000794 [condensed nuclear chromosome]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0004520 [endodeoxyribonuclease activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005815 [microtubule organizing center]
GO:0006268 [DNA unwinding involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006310 [DNA recombination]
GO:0006312 [mitotic recombination]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007126 [meiotic nuclear division]
GO:0007131 [reciprocal meiotic recombination]
GO:0008022 [protein C-terminus binding]
GO:0008094 [DNA-dependent ATPase activity]
GO:0010569 [regulation of double-strand break repair via homologous recombination]
GO:0016605 [PML body]
GO:0031297 [replication fork processing]
GO:0035861 [site of double-strand break]
GO:0042148 [strand invasion]
GO:0042802 [identical protein binding]
GO:0043142 [single-stranded DNA-dependent ATPase activity]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051106 [positive regulation of DNA ligation]
GO:0051260 [protein homooligomerization]
GO:0070182 [DNA polymerase binding]
GO:0070192 [chromosome organization involved in meiosis]
GO:0071479 [cellular response to ionizing radiation]
GO:0072757 [cellular response to camptothecin]
GO:1990426 [homologous recombination-dependent replication fork processing]
Show all
 280 aa
31 kDa 		No 0
RAD51-003
ENSP00000454176
ENST00000557850
Q06609 [Direct mapping]
DNA repair protein RAD51 homolog 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000150 [recombinase activity]
GO:0000166 [nucleotide binding]
GO:0000228 [nuclear chromosome]
GO:0000400 [four-way junction DNA binding]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000785 [chromatin]
GO:0000793 [condensed chromosome]
GO:0000794 [condensed nuclear chromosome]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0004520 [endodeoxyribonuclease activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005815 [microtubule organizing center]
GO:0006259 [DNA metabolic process]
GO:0006268 [DNA unwinding involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006310 [DNA recombination]
GO:0006312 [mitotic recombination]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007126 [meiotic nuclear division]
GO:0007131 [reciprocal meiotic recombination]
GO:0008022 [protein C-terminus binding]
GO:0008094 [DNA-dependent ATPase activity]
GO:0010569 [regulation of double-strand break repair via homologous recombination]
GO:0016605 [PML body]
GO:0031297 [replication fork processing]
GO:0035861 [site of double-strand break]
GO:0042148 [strand invasion]
GO:0042802 [identical protein binding]
GO:0043142 [single-stranded DNA-dependent ATPase activity]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051106 [positive regulation of DNA ligation]
GO:0051260 [protein homooligomerization]
GO:0070182 [DNA polymerase binding]
GO:0070192 [chromosome organization involved in meiosis]
GO:0071479 [cellular response to ionizing radiation]
GO:0072757 [cellular response to camptothecin]
GO:1990426 [homologous recombination-dependent replication fork processing]
Show all
 242 aa
26.4 kDa 		No 0
RAD51-006
ENSP00000431897
ENST00000526763
Q9NZG9 [Direct mapping]
DNA repair protein RAD51 homolog 1; RAD51
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
Show all
 75 aa
8.2 kDa 		No 0
RAD51-007
ENSP00000432759
ENST00000527860
E9PNT5 [Direct mapping]
DNA repair protein RAD51 homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003677 [DNA binding]
GO:0005524 [ATP binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0008094 [DNA-dependent ATPase activity]
Show all
 172 aa
18.8 kDa 		No 0
RAD51-008
ENSP00000433924
ENST00000532743
Q06609 [Direct mapping]
DNA repair protein RAD51 homolog 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000150 [recombinase activity]
GO:0000166 [nucleotide binding]
GO:0000228 [nuclear chromosome]
GO:0000400 [four-way junction DNA binding]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000785 [chromatin]
GO:0000793 [condensed chromosome]
GO:0000794 [condensed nuclear chromosome]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0004520 [endodeoxyribonuclease activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005815 [microtubule organizing center]
GO:0006259 [DNA metabolic process]
GO:0006268 [DNA unwinding involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006310 [DNA recombination]
GO:0006312 [mitotic recombination]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007126 [meiotic nuclear division]
GO:0007131 [reciprocal meiotic recombination]
GO:0008022 [protein C-terminus binding]
GO:0008094 [DNA-dependent ATPase activity]
GO:0010569 [regulation of double-strand break repair via homologous recombination]
GO:0016605 [PML body]
GO:0031297 [replication fork processing]
GO:0035861 [site of double-strand break]
GO:0042148 [strand invasion]
GO:0042802 [identical protein binding]
GO:0043142 [single-stranded DNA-dependent ATPase activity]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051106 [positive regulation of DNA ligation]
GO:0051260 [protein homooligomerization]
GO:0070182 [DNA polymerase binding]
GO:0070192 [chromosome organization involved in meiosis]
GO:0071479 [cellular response to ionizing radiation]
GO:0072757 [cellular response to camptothecin]
GO:1990426 [homologous recombination-dependent replication fork processing]
Show all
 340 aa
36.8 kDa 		No 0
RAD51-009
ENSP00000372088
ENST00000382643
Q06609 [Direct mapping]
DNA repair protein RAD51 homolog 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000150 [recombinase activity]
GO:0000166 [nucleotide binding]
GO:0000228 [nuclear chromosome]
GO:0000400 [four-way junction DNA binding]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000785 [chromatin]
GO:0000793 [condensed chromosome]
GO:0000794 [condensed nuclear chromosome]
GO:0000800 [lateral element]
GO:0001932 [regulation of protein phosphorylation]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0004520 [endodeoxyribonuclease activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005815 [microtubule organizing center]
GO:0006259 [DNA metabolic process]
GO:0006268 [DNA unwinding involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006310 [DNA recombination]
GO:0006312 [mitotic recombination]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007126 [meiotic nuclear division]
GO:0007127 [meiosis I]
GO:0007131 [reciprocal meiotic recombination]
GO:0008022 [protein C-terminus binding]
GO:0008094 [DNA-dependent ATPase activity]
GO:0009636 [response to toxic substance]
GO:0010165 [response to X-ray]
GO:0010569 [regulation of double-strand break repair via homologous recombination]
GO:0014070 [response to organic cyclic compound]
GO:0016605 [PML body]
GO:0031297 [replication fork processing]
GO:0032200 [telomere organization]
GO:0035861 [site of double-strand break]
GO:0042148 [strand invasion]
GO:0042493 [response to drug]
GO:0042802 [identical protein binding]
GO:0043142 [single-stranded DNA-dependent ATPase activity]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051106 [positive regulation of DNA ligation]
GO:0051260 [protein homooligomerization]
GO:0070182 [DNA polymerase binding]
GO:0070192 [chromosome organization involved in meiosis]
GO:0071312 [cellular response to alkaloid]
GO:0071479 [cellular response to ionizing radiation]
GO:0071480 [cellular response to gamma radiation]
GO:0072711 [cellular response to hydroxyurea]
GO:0072719 [cellular response to cisplatin]
GO:0072757 [cellular response to camptothecin]
GO:1902521 [response to etoposide]
GO:1990414 [replication-born double-strand break repair via sister chromatid exchange]
GO:1990426 [homologous recombination-dependent replication fork processing]
Show all
 340 aa
36.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.