Cell atlas - MCF2L2 - The Human Protein Atlas

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MCF2L2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	MCF2L2
Gene description	MCF.2 cell line derived transforming sequence-like 2
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & cytosol.
RNA cell category	Cell line enhanced (HDLM-2, Karpas-707)
Protein evidence	Evidence at transcript level
Main location	Localized to the Plasma membrane (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA038947
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HDLM-2, Karpas-707) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & cytosol.

Main location

Plasma membrane (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA038947	A-431	Plasma membrane
	HPA038947	A-431	Cytosol
	HPA038947	U-2 OS	Plasma membrane
	HPA038947	U-2 OS	Cytosol
	HPA038947	U-251 MG	Plasma membrane
	HPA038947	U-251 MG	Cytosol

GENE INFORMATION
Gene name	MCF2L2 (HGNC Symbol)
Synonyms	ARHGEF22, KIAA0861
Description	MCF.2 cell line derived transforming sequence-like 2 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q27.1
Chromosome location (bp)	183178043 - 183428778
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000053524 (version 83.38)
Entrez gene	23101
UniProt	Q86YR7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q86YR7
Antibodypedia	MCF2L2 antibodies

PROTEIN BROWSER

MCF2L2-001	MCF2L2-003	MCF2L2-004	MCF2L2-008	MCF2L2-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MCF2L2-001 ENSP00000328118 ENST00000328913	Q86YR7 [Direct mapping] Probable guanine nucleotide exchange factor MCF2L2 Show all	Phobius predicted membrane proteins Predicted intracellular proteins Disease related genes Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	1114 aa 127 kDa	No	0
MCF2L2-003 ENSP00000414131 ENST00000414362	Q86YR7 [Direct mapping] Probable guanine nucleotide exchange factor MCF2L2 Show all	Phobius predicted membrane proteins Predicted intracellular proteins Disease related genes Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	628 aa 71.9 kDa	No	0
MCF2L2-004 ENSP00000388190 ENST00000447025	Q86YR7 [Direct mapping] Probable guanine nucleotide exchange factor MCF2L2 Show all	Phobius predicted membrane proteins Predicted intracellular proteins Disease related genes Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	711 aa 81.9 kDa	No	0
MCF2L2-008 ENSP00000420070 ENST00000473233	Q86YR7 [Direct mapping] Probable guanine nucleotide exchange factor MCF2L2 Show all	Phobius predicted membrane proteins Predicted intracellular proteins Disease related genes Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	1074 aa 122.9 kDa	No	0
MCF2L2-010 ENSP00000417345 ENST00000482017	C9J326 [Direct mapping] Probable guanine nucleotide exchange factor MCF2L2 Show all	Phobius predicted membrane proteins Predicted intracellular proteins Show all		124 aa 14.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.