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Cancer tissues showed in most cases weak nuclear staining or were negative. Thyroid and head neck cancer as well as several breast, ovarian, cervical and pancreatic cancers displayed moderate nuclear positivity.
GENE INFORMATION
Gene name
ARID4B (HGNC Symbol)
Synonyms
BCAA, BRCAA1, RBP1L1, SAP180
Description
AT rich interactive domain 4B (RBP1-like) (HGNC Symbol)
Entrez gene summary
This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
Q4LE39 [Direct mapping] AT-rich interactive domain-containing protein 4B
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Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
X6RCR8 [Direct mapping] AT-rich interactive domain-containing protein 4B
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Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0044212 [transcription regulatory region DNA binding]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003674 [molecular_function] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006325 [chromatin organization] GO:0006349 [regulation of gene expression by genetic imprinting] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007283 [spermatogenesis] GO:0008150 [biological_process] GO:0010467 [gene expression] GO:0034773 [histone H4-K20 trimethylation] GO:0036124 [histone H3-K9 trimethylation] GO:0040029 [regulation of gene expression, epigenetic] GO:0044212 [transcription regulatory region DNA binding] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0097368 [establishment of Sertoli cell barrier]
