Expression of HHAT in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Hedgehog acyltransferase

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA016462

GENE INFORMATION
Gene name	HHAT (HGNC Symbol)
Synonyms	FLJ10724, GUP2, MART-2, MART2, rasp, sit, ski, Skn
Description	Hedgehog acyltransferase (HGNC Symbol)
Entrez gene summary	'Skinny hedgehog' (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of 'hedgehog' (see MIM 600725).[supplied by OMIM, Jul 2002]
Chromosome	1
Cytoband	q32.2
Chromosome location (bp)	210328252 - 210676296
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000054392 (version 83.38)
Entrez gene	55733
UniProt	Q5VTY9 (UniProt - Evidence at protein level)
neXtProt	NX_Q5VTY9
Antibodypedia	HHAT antibodies

PROTEIN BROWSER

HHAT-001	HHAT-002	HHAT-003	HHAT-004	HHAT-201	HHAT-202	HHAT-203	HHAT-204	HHAT-205

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HHAT-001 ENSP00000261458 ENST00000261458	Q5VTY9 [Direct mapping] Protein-cysteine N-palmitoyltransferase HHAT Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005525 [GTP binding] GO:0005789 [endoplasmic reticulum membrane] GO:0007275 [multicellular organismal development] GO:0016021 [integral component of membrane] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	493 aa 57.3 kDa	No	>9
HHAT-002 ENSP00000355976 ENST00000367009	B1AK61 [Direct mapping] Protein-cysteine N-palmitoyltransferase HHAT; cDNA FLJ34867 fis, clone NT2NE2014176, highly similar to Protein-cysteine N-palmitoyltransferase HHAT (EC 2.3.1.-) Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016740 [transferase activity] Show all	183 aa 20.8 kDa	No	4
HHAT-003 ENSP00000413399 ENST00000426968	A0A075B6R5 [Direct mapping] Protein-cysteine N-palmitoyltransferase HHAT Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	207 aa 24.2 kDa	Yes	4
HHAT-004 ENSP00000355977 ENST00000367010	Q5VTY9 [Direct mapping] Protein-cysteine N-palmitoyltransferase HHAT Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005525 [GTP binding] GO:0005789 [endoplasmic reticulum membrane] GO:0007275 [multicellular organismal development] GO:0016021 [integral component of membrane] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	493 aa 57.3 kDa	No	>9
HHAT-201 ENSP00000416845 ENST00000413764	Q5VTY9 [Direct mapping] Protein-cysteine N-palmitoyltransferase HHAT Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005525 [GTP binding] GO:0005789 [endoplasmic reticulum membrane] GO:0007275 [multicellular organismal development] GO:0016021 [integral component of membrane] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	493 aa 57.3 kDa	No	>9
HHAT-202 ENSP00000442625 ENST00000537898	Q5VTY9 [Direct mapping] Protein-cysteine N-palmitoyltransferase HHAT Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005525 [GTP binding] GO:0005789 [endoplasmic reticulum membrane] GO:0007275 [multicellular organismal development] GO:0016021 [integral component of membrane] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	428 aa 49.9 kDa	No	>9
HHAT-203 ENSP00000444995 ENST00000541565	Q5VTY9 [Direct mapping] Protein-cysteine N-palmitoyltransferase HHAT Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005525 [GTP binding] GO:0005789 [endoplasmic reticulum membrane] GO:0007275 [multicellular organismal development] GO:0016021 [integral component of membrane] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	356 aa 41.1 kDa	No	8
HHAT-204 ENSP00000438468 ENST00000545154	Q5VTY9 [Direct mapping] Protein-cysteine N-palmitoyltransferase HHAT Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005525 [GTP binding] GO:0005789 [endoplasmic reticulum membrane] GO:0007224 [smoothened signaling pathway] GO:0007275 [multicellular organismal development] GO:0016021 [integral component of membrane] GO:0016409 [palmitoyltransferase activity] GO:0018345 [protein palmitoylation] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	494 aa 57 kDa	No	>9
HHAT-205 ENSP00000439229 ENST00000545781	F5H2Y1 [Direct mapping] Protein-cysteine N-palmitoyltransferase HHAT Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0016021 [integral component of membrane] Show all	82 aa 9.3 kDa	No	0