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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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FOXC1
  • TISSUE

  • premium

    CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

Forkhead box C1

Protein class

Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA040670

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignant tissues showed weak to moderate nuclear and/or cytoplasmic staining. Several liver, renal, endometrial, stomach cancers, malignant lymphomas and melanomas were negative.

GENE INFORMATION

Gene name

FOXC1 (HGNC Symbol)

Synonyms

ARA, FKHL7, FREAC3, IGDA, IHG1, IRID1

Description

Forkhead box C1 (HGNC Symbol)

Entrez gene summary

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p25.3

Chromosome location (bp)

1609972 - 1613897

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000054598 (version 83.38)

Entrez gene

2296

UniProt

Q12948 (UniProt - Evidence at protein level)

neXtProt

NX_Q12948

Antibodypedia

FOXC1 antibodies

PROTEIN BROWSER

FOXC1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FOXC1-001
ENSP00000370256
ENST00000380874
Q12948 [Direct mapping]
Forkhead box protein C1
W6CJ52 [Target identity:100%; Query identity:100%]
Forkhead box C1; Forkhead box C1 protein
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001501 [skeletal system development]
GO:0001503 [ossification]
GO:0001541 [ovarian follicle development]
GO:0001568 [blood vessel development]
GO:0001654 [eye development]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0001756 [somitogenesis]
GO:0001822 [kidney development]
GO:0001945 [lymph vessel development]
GO:0001974 [blood vessel remodeling]
GO:0003007 [heart morphogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005720 [nuclear heterochromatin]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007219 [Notch signaling pathway]
GO:0007420 [brain development]
GO:0007507 [heart development]
GO:0008134 [transcription factor binding]
GO:0008283 [cell proliferation]
GO:0008301 [DNA binding, bending]
GO:0008354 [germ cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0014031 [mesenchymal cell development]
GO:0014032 [neural crest cell development]
GO:0016477 [cell migration]
GO:0016525 [negative regulation of angiogenesis]
GO:0030154 [cell differentiation]
GO:0030199 [collagen fibril organization]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0032808 [lacrimal gland development]
GO:0035050 [embryonic heart tube development]
GO:0036438 [maintenance of lens transparency]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0043010 [camera-type eye development]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046620 [regulation of organ growth]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048341 [paraxial mesoderm formation]
GO:0048762 [mesenchymal cell differentiation]
GO:0048844 [artery morphogenesis]
GO:0050880 [regulation of blood vessel size]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060038 [cardiac muscle cell proliferation]
GO:1901491 [negative regulation of lymphangiogenesis]
GO:1901534 [positive regulation of hematopoietic progenitor cell differentiation]
GO:1902038 [positive regulation of hematopoietic stem cell differentiation]
GO:1902257 [negative regulation of apoptotic process involved in outflow tract morphogenesis]
Show all
553 aa
56.8 kDa
No 0

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