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Most malignant tissues showed weak to moderate nuclear and/or cytoplasmic staining. Several liver, renal, endometrial, stomach cancers, malignant lymphomas and melanomas were negative.
GENE INFORMATION
Gene name
FOXC1 (HGNC Symbol)
Synonyms
ARA, FKHL7, FREAC3, IGDA, IHG1, IRID1
Description
Forkhead box C1 (HGNC Symbol)
Entrez gene summary
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq, Jul 2008]
Q12948 [Direct mapping] Forkhead box protein C1 W6CJ52 [Target identity:100%; Query identity:100%] Forkhead box C1; Forkhead box C1 protein
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Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Disease related genes Protein evidence (Ezkurdia et al 2014)
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GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001501 [skeletal system development] GO:0001503 [ossification] GO:0001541 [ovarian follicle development] GO:0001568 [blood vessel development] GO:0001654 [eye development] GO:0001657 [ureteric bud development] GO:0001701 [in utero embryonic development] GO:0001756 [somitogenesis] GO:0001822 [kidney development] GO:0001945 [lymph vessel development] GO:0001974 [blood vessel remodeling] GO:0003007 [heart morphogenesis] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005720 [nuclear heterochromatin] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007219 [Notch signaling pathway] GO:0007420 [brain development] GO:0007507 [heart development] GO:0008134 [transcription factor binding] GO:0008283 [cell proliferation] GO:0008301 [DNA binding, bending] GO:0008354 [germ cell migration] GO:0010628 [positive regulation of gene expression] GO:0014031 [mesenchymal cell development] GO:0014032 [neural crest cell development] GO:0016477 [cell migration] GO:0016525 [negative regulation of angiogenesis] GO:0030154 [cell differentiation] GO:0030199 [collagen fibril organization] GO:0030203 [glycosaminoglycan metabolic process] GO:0032808 [lacrimal gland development] GO:0035050 [embryonic heart tube development] GO:0036438 [maintenance of lens transparency] GO:0038084 [vascular endothelial growth factor signaling pathway] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0043010 [camera-type eye development] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045930 [negative regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046620 [regulation of organ growth] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048341 [paraxial mesoderm formation] GO:0048762 [mesenchymal cell differentiation] GO:0048844 [artery morphogenesis] GO:0050880 [regulation of blood vessel size] GO:0055010 [ventricular cardiac muscle tissue morphogenesis] GO:0060038 [cardiac muscle cell proliferation] GO:1901491 [negative regulation of lymphangiogenesis] GO:1901534 [positive regulation of hematopoietic progenitor cell differentiation] GO:1902038 [positive regulation of hematopoietic stem cell differentiation] GO:1902257 [negative regulation of apoptotic process involved in outflow tract morphogenesis]