Expression of CHRDL2 in cancer - Summary

CANCER ATLAS

Gene description

Chordin-like 2

Protein class

Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA021771

GENE INFORMATION
Gene name	CHRDL2 (HGNC Symbol)
Synonyms	BNF1
Description	Chordin-like 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the chordin family of proteins. Chordin family members are secreted proteins that share a cysteine-rich pro-collagen repeat domain and associate with members of the transforming growth factor beta superfamily. In vitro assays demonstrate a direct interaction between the encoded protein and human activin A. This gene is expressed in many tissues including osteoblasts, where it is differentially expressed during differentiation. In addition, its expression is upregulated in human osteoarthritic joint cartilage, suggesting a role in adult cartilage regeneration. [provided by RefSeq, Jan 2015]
Chromosome	11
Cytoband	q13.4
Chromosome location (bp)	74696429 - 74731385
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000054938 (version 83.38)
Entrez gene	25884
UniProt	Q6WN34 (UniProt - Evidence at protein level)
neXtProt	NX_Q6WN34
Antibodypedia	CHRDL2 antibodies

PROTEIN BROWSER

CHRDL2-001	CHRDL2-002	CHRDL2-003	CHRDL2-009	CHRDL2-010	CHRDL2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHRDL2-001 ENSP00000263671 ENST00000263671	Q6WN34 [Direct mapping] Chordin-like protein 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001503 [ossification] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0030154 [cell differentiation] GO:0030514 [negative regulation of BMP signaling pathway] GO:0051216 [cartilage development] Show all	451 aa 49.7 kDa	Yes	0
CHRDL2-002 ENSP00000365510 ENST00000376332	Q6WN34 [Direct mapping] Chordin-like protein 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001503 [ossification] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0051216 [cartilage development] Show all	429 aa 47.5 kDa	Yes	0
CHRDL2-003 ENSP00000431380 ENST00000528789	Q6WN33 [Direct mapping] Chordin-like protein 2; Chordin-related protein 2 variant III Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	308 aa 33.9 kDa	Yes	0
CHRDL2-009 ENSP00000434257 ENST00000525413	H0YDT1 [Direct mapping] Chordin-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	177 aa 19.1 kDa	No	0
CHRDL2-010 ENSP00000432345 ENST00000529912	H0YCU0 [Direct mapping] Chordin-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		91 aa 9.9 kDa	No	0
CHRDL2-201 ENSP00000482669 ENST00000622063	A0A087WZH6 [Direct mapping] Chordin-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	281 aa 30.6 kDa	No	0