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CUL1

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GENERAL INFORMATION

Gene name

 CUL1

Gene description

 Cullin 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus. In addition localized to the nucleoli.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported)

Additional location

 In addition localized to the Nucleoli (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
CAB002676 , HPA064584
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus. In addition localized to the nucleoli.

Main location

 Nucleus (supported)

Additional location

 Nucleoli (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB002676 A-431 Nucleus Intensity
CAB002676 U-251 MG Nucleus Intensity
HPA064584 PC-3 Nucleus
Nucleoli
HPA064584 SiHa Nucleus
Nucleoli
HPA064584 U-2 OS Nucleus

GENE INFORMATION

Gene name

 CUL1

Synonyms

Description

 Cullin 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 7

Cytoband

 q36.1

Chromosome location (bp)

 148697914 - 148801036

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000055130 (version 83.38)

Entrez gene

 8454

UniProt

 Q13616 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13616

Antibodypedia

 CUL1 antibodies

PROTEIN BROWSER
CUL1-001
CUL1-002
CUL1-003
CUL1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CUL1-001
ENSP00000387160
ENST00000409469
Q13616 [Direct mapping]
Cullin-1
A0A090N7U0 [Target identity:100%; Query identity:100%]
Cullin 1; Cullin 1, isoform CRA_b
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007050 [cell cycle arrest]
GO:0007219 [Notch signaling pathway]
GO:0007623 [circadian rhythm]
GO:0008285 [negative regulation of cell proliferation]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031461 [cullin-RING ubiquitin ligase complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0045087 [innate immune response]
GO:0050852 [T cell receptor signaling pathway]
GO:0051403 [stress-activated MAPK cascade]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0061630 [ubiquitin protein ligase activity]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1990452 [Parkin-FBXW7-Cul1 ubiquitin ligase complex]
Show all
 776 aa
89.7 kDa 		No 0
CUL1-002
ENSP00000326804
ENST00000325222
Q13616 [Direct mapping]
Cullin-1
A0A090N7U0 [Target identity:100%; Query identity:100%]
Cullin 1; Cullin 1, isoform CRA_b
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006513 [protein monoubiquitination]
GO:0006915 [apoptotic process]
GO:0007050 [cell cycle arrest]
GO:0007219 [Notch signaling pathway]
GO:0007623 [circadian rhythm]
GO:0008283 [cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0009887 [organ morphogenesis]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031461 [cullin-RING ubiquitin ligase complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0045087 [innate immune response]
GO:0050852 [T cell receptor signaling pathway]
GO:0051403 [stress-activated MAPK cascade]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0061630 [ubiquitin protein ligase activity]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1990452 [Parkin-FBXW7-Cul1 ubiquitin ligase complex]
Show all
 776 aa
89.7 kDa 		No 0
CUL1-003
ENSP00000473318
ENST00000602748
Q13616 [Direct mapping]
Cullin-1
A0A090N7U0 [Target identity:100%; Query identity:100%]
Cullin 1; Cullin 1, isoform CRA_b
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007050 [cell cycle arrest]
GO:0007219 [Notch signaling pathway]
GO:0007623 [circadian rhythm]
GO:0008285 [negative regulation of cell proliferation]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031461 [cullin-RING ubiquitin ligase complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0045087 [innate immune response]
GO:0050852 [T cell receptor signaling pathway]
GO:0051403 [stress-activated MAPK cascade]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0061630 [ubiquitin protein ligase activity]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1990452 [Parkin-FBXW7-Cul1 ubiquitin ligase complex]
Show all
 776 aa
89.7 kDa 		No 0
CUL1-201
ENSP00000482123
ENST00000617797
A0A0C4DGX4 [Direct mapping]
Cullin-1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0031461 [cullin-RING ubiquitin ligase complex]
GO:0031625 [ubiquitin protein ligase binding]
Show all
 752 aa
87.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.