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USP36

GENERAL INFORMATION

Gene name

 USP36

Gene description

 Ubiquitin specific peptidase 36

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 13
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in several different tissue types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA012082
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Oral mucosa

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin010203040TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin0510152025RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina020406080100Tags Per Million

GENE INFORMATION

Gene name

 USP36 (HGNC Symbol)

Synonyms

 FLJ12851, KIAA1453

Description

 Ubiquitin specific peptidase 36 (HGNC Symbol)

Entrez gene summary

 Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP36 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Jan 2009]

Chromosome

 17

Cytoband

 q25.3

Chromosome location (bp)

 78787381 - 78841441

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000055483 (version 83.38)

Entrez gene

 57602

UniProt

 Q9P275 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9P275

Antibodypedia

 USP36 antibodies

PROTEIN BROWSER
«
USP36-002
USP36-003
USP36-004
USP36-010
USP36-011
USP36-012
USP36-014
USP36-015
USP36-018
USP36-021
USP36-029
USP36-201
USP36-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
USP36-002
ENSP00000467682
ENST00000590546
Q8IXW9 [Direct mapping]
USP36 protein; Ubiquitin carboxyl-terminal hydrolase 36
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 285 aa
31.8 kDa 		No 0
USP36-003
ENSP00000441214
ENST00000542802
Q9P275 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 36
A0A024R8V6 [Target identity:100%; Query identity:100%]
Ubiquitin carboxyl-terminal hydrolase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:1903146 [regulation of mitophagy]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 1123 aa
122.9 kDa 		No 0
USP36-004
ENSP00000465698
ENST00000592231
K7EKN3 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 36
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 69 aa
8.3 kDa 		No 0
USP36-010
ENSP00000466212
ENST00000592275
K7ELT3 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 36
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 80 aa
8.7 kDa 		No 0
USP36-011
ENSP00000465183
ENST00000588365
K7EJI3 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 36
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 53 aa
5.8 kDa 		No 0
USP36-012
ENSP00000467520
ENST00000586531
K7EPT1 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 36
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 179 aa
19.8 kDa 		No 0
USP36-014
ENSP00000468194
ENST00000587783
K7ERC1 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 36
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 67 aa
7.4 kDa 		No 0
USP36-015
ENSP00000467951
ENST00000586896
K7EQS0 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 36
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 159 aa
17.6 kDa 		No 0
USP36-018
ENSP00000466187
ENST00000589424
K7ELR5 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 36
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 234 aa
26.1 kDa 		No 0
USP36-021
ENSP00000466567
ENST00000586066
K7EMM6 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 36
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 259 aa
29 kDa 		No 0
USP36-029
ENSP00000464746
ENST00000588130
K7EIH0 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 36
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 101 aa
11.9 kDa 		No 0
USP36-201
ENSP00000310590
ENST00000312010
Q9P275 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 36
A0A024R8V6 [Target identity:100%; Query identity:100%]
Ubiquitin carboxyl-terminal hydrolase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:1903146 [regulation of mitophagy]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 1123 aa
122.9 kDa 		No 0
USP36-202
ENSP00000401119
ENST00000449938
E9PEW0 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 548 aa
60.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.